MOTOR CONTROL DEFICITS IN PARKINSONS DISEASE

帕金森病的运动控制缺陷

• 批准号: 2892255
• 负责人: Howard Poizner
• 金额: $ 22.66万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2892255
• 关键词: Parkinson's disease; abnormal involuntary movement; clinical research; fingers; human subject; joints; limb movement; memory; neural information processing; neuromuscular system; psychomotor function; sensorimotor system; sensory discrimination; space perception; vision; visual feedback

DESCRIPTION (Adapted from Applicant's Abstract): This proposal undertakes the first systematic motion analyses of the performance of subjects with Parkinson's Disease (PD) in executing unconstrained, multi-joint 3D reaching movements. The focus is on uncovering the role that the basal ganglia may play in integrating sensory information from different sources into the motor plan. Three-dimensional pointing errors, movement kinematics, and interjoint coordination will be analyzed. Experiments utilize a programmable robot arm to present targets in known locations in one of two planes in space. Subjects will perform movements under a range of conditions which vary the available sensory information, memory demands, and task constraints. Spatial Perception Thresholds. Pure perceptual errors will be measured by having subjects' visually discriminate actual target locations from nearby locations presented 1-2 sec earlier and then extinguished. Pointing to Visually Defined Actual and Memorized Targets With and Without Vision of the Moving Arm. Disturbances in pointing movements to targets performed in darkened room will be investigated under different conditions of visual feedback: no visual feedback during the movement; vision of the moving fingertip but not of the target; vision of the target but not of the finger; vision of the fingertip and the target. Pointing to Memorized Targets Defined Proprioceptively. Two modes of proprioceptive target presentation will be used that will allow or prevent the subject from having access to central control signals underlying the arm movement. Pointing to Memorized Targets Defined Cutaneously. Disturbances in pointing movements to somatosensory targets also will be analyzed and compared to disturbances for visually or proprioceptively presented targets. Movement Speed Regulation: Peripheral Deficits versus Central Strategy Adaptation. Movements to memorize targets performed at different speeds with and without vision of the arm will be compared. Comparison Across Patient Groups. Finally, data on Parkinsonian subjects will be compared with separate data acquired on subjects lacking proprioceptive information from their limbs as well as subjects with unilateral cortical lesions. This combination of movement analyses with behavioral manipulations allows characterization of deficient motor performance and the ability to dissect out those elements of sensorimotor processing which may be most impaired in Parkinsonism.

描述（根据申请人的摘要改编）：该提案承担 受试者表现的第一个系统运动分析 帕金森氏病（PD）在执行无约束的多关节3D到达 动作。 重点是揭示基底神经节的作用 播放来自不同来源的感官信息 电机计划。 三维指向错误，运动运动学和 将分析间协调。 实验利用a 可编程机器人臂以在两个之一的已知位置呈现目标 太空中的飞机。 受试者将在一定范围内执行运动 改变可用的感官信息，内存需求和 任务约束。 空间感知阈值。 纯粹的感知错误 将通过让受试者的视觉区分实际目标来衡量 附近地点的位置提前1-2秒，然后 熄灭。 指向视觉定义的实际和记忆目标 有和没有移动手臂的视力。指向的干扰 在黑暗房间内执行的目标的动作将在下面调查 视觉反馈的不同条件：没有视觉反馈 移动;移动指尖的视力，而不是目标；愿景 目标但不是手指的目标；指尖和目标的视力。 指出记忆的目标定义了本体定义。 两种模式 将使用允许或阻止的本体感受目标表现 该主题可以访问手臂下方的中央控制信号 移动。 指出记忆的目标是皮肤的。 干扰 还将分析指向运动目标的运动，并将 与视觉或本体感知性呈现的目标相比。 运动速度法规：外围缺陷与中央策略 适应。 动作以记住以不同速度执行的目标 将比较有或没有武器的视力。 进行比较 患者群体。 最后，将比较帕金森氏症科目的数据 在缺乏本体感受信息的受试者上获得的单独数据 从四肢以及具有单侧皮质病变的受试者。 这 运动分析与行为操纵的结合允许 运动性能不足和剖析能力的表征 消除可能受到最大损害的感觉运动处理元素 帕金森主义。