FUNCTIONAL RECOVERY--NEUROGENESIS AND SOCIAL ENVIRONMENT

功能恢复--神经发生和社会环境

• 批准号: 2839420
• 负责人: MEI-FANG CHENG
• 金额: $ 17.08万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2839420
• 关键词: Aves; RNA binding protein; behavioral /social science research tag; biomarker; brain injury; estradiol; experimental brain lesion; functional ability; gender difference; hormone regulation /control mechanism; hypothalamus; immunocytochemistry; neural plasticity; neurogenesis; phenotype; progesterone; sex behavior; socioenvironment; testosterone

DESCRIPTION (adapted from applicant's abstract): The long term objective of this proposal is to investigate the underlying mechanisms of brain repair. A normal brain receives stimuli and information and responds to its environment. A damaged brain attempts the same process, but has the added task of reorganization through interactions between neurons and the immediate and external environments. Post-traumatic environmental conditions, both physical and social, can enhance or impede the brain repair process. In this proposal, experiments are proposed to explore and identify aspects of social properties that facilitate brain recovery and the role of neurogenesis in the improvement of brain function. Specifically, discrete lesions in the hypothalamus will be used to experimentally render male ring doves unable to perform courtship behaviors when initially introduced to a female. It has previously been shown that housing a male who has lesion damage with a mature female will facilitate the full recovery of courtship behavior. In experiments designed to determine which environmental factors may play a role in the reinstatement of courtship behavior, brain damaged males will be exposed to a variety of social conditions. Additionally, preliminary studies of adult ring doves strongly suggest that brain lesions dramatically increase ventricular mitotic activity. With the use of the Hu protein (a family of neuronal RNA-binding proteins) as an early marker of neuronal phenotypic differentiation, the PI plans to demonstrate that neurogenesis is promoted by brain lesions and to explicate the role of neurogenesis in brain repair. Despite a recent surge in the study of brain repair, the possible role played by neurogenesis in the recovery of function have been virtually ignored. Results of the proposed studies will address this question directly and may lead to a promising new direction for the investigation of mechanisms of brain repair after injury.

描述（改编自申请人的摘要）： 该建议是研究脑修复的潜在机制。 正常的大脑会收到刺激和信息，并响应其 环境。 损坏的大脑尝试相同的过程，但增加了 通过神经元与 直接和外部环境。 创伤后环境 身体和社交的条件都可以增强或阻碍大脑修复 过程。 在此提案中，提出了实验来探索和识别方面 促进大脑恢复和作用的社会特性 神经发生在改善大脑功能方面。 具体来说，离散 下丘脑中的病变将用于实验呈现雄性环 鸽子最初引入一个 女性。 以前已经证明，住房有病变的男性 成熟的女性损害将有助于全面恢复求爱 行为。 在旨在确定哪些环境因素的实验中 可能在恢复求爱行为的情况下发挥作用，大脑受损 男性将面临各种社会条件。 此外， 成年环鸽的初步研究强烈表明脑部病变 急剧增加心室有丝分裂活性。 使用胡 蛋白质（神经元RNA结合蛋白的家族）作为早期标记 神经元表型分化，PI计划证明 神经发生是通过脑病变促进的，并解释了 脑修复中的神经发生。 尽管最近的脑修复研究激增，但可能的作用 神经发生在功能恢复中扮演的实际上已经是 被忽略。 拟议研究的结果将解决这个问题 直接并可能导致调查的新方向 受伤后大脑修复机制。