CEREBELLAR CONTRIBUTION TO ADAPTIVE REACHING BEHAVIORS

小脑对适应性触及行为的贡献

• 批准号: 6071633
• 负责人: JAMES R BLOEDEL
• 金额: $ 5万
• 依托单位: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6071633
• 关键词: behavioral /social science research tag; cats; cerebellar disorders; cerebellum; clinical research; electrophysiology; human subject; learning; limb movement; psychological adaptation; psychomotor function; visual perception

DESCRIPTION (from applicant's abstract) The experiments proposed in this grant request are designed to examine the role of the cerebellum in the learning of two different cerebellar-dependent adaptive reaching movements, one to compensate for image displacing prisms and the other to compensate for the application of an elastic load capable of displacing the limb from its intended trajectory. The experiments assess the general hypothesis that the cerebellum's role in the learning of motor tasks is highly task-dependent. In the first group of experiments, the contribution of the cerebellum to prism adaptation will be explored in human subjects and in cats trained to reach for a manipulandum while wearing image displacing prisms. Our preliminary data indicate that this compensatory process is dependent on the cerebellum, but in a different manner than currently believed. In a second group of studies, human subjects and cats will be required to adapt to the application of an elastic load applied during a reaching movement. Preliminary studies indicate that this adaptation employs a response to the perturbation that is highly dependent upon on-line processing by the cerebellum. The experiments will determine the capacity of cerebellar patients and cats with inactivated ipsilateral interposed and dentate nuclei to acquire and retain these two types of adaptive behaviors. The cerebellar-dependent features of the adaptation acquired normally will be contrasted with those governing adaptation when the cerebellum is dysfunctional. The cat paradigms will be used to asses the neuronal interactions occurring in the cerebellum underlying the acquisition as well as the execution of these two types of adaptive behaviors. Multiple single unit recording in functionally related regions of the cerebellar cortex and nuclei will elucidate the neuronal interactions within a specific sagittal zone during both the acquisition and performance of these adaptive behaviors, emphasizing those interactions related to the cerebellar-dependent features of the learning process. The findings will reveal important principles related to the learning of motor behaviors, the basis for certain functional abnormalities in cerebellar patients, and general mechanisms which may be invoked during recovery of motor function following ablative pathology in the central nervous system.

描述（来自申请人的摘要）在此提出的实验 授予请求旨在检查小脑在 学习两个不同小脑依赖性的自适应运动运动， 一个用于补偿棱镜的图像，另一个用于补偿 用于应用弹性负载，能够将肢体从 它的预期轨迹。 实验评估了以下一般假设 小脑在学习运动任务中的作用很高 任务依赖。 在第一组实验中， 将在人类主题和 穿着图像流离失所的猫训练了可以伸手去拿的 棱镜。 我们的初步数据表明，这种补偿过程是 取决于小脑，但与当前不同 相信。 在第二组研究中，人类受试者和猫将是 需要适应在A期间施加的弹性负载的应用 到达运动。 初步研究表明这种适应 采用对扰动的反应，高度依赖于在线 小脑加工。 实验将确定小脑患者和猫的能力 灭活的同侧插入和齿状核获取，并且 保留这两种类型的自适应行为。 小脑依赖性 正常获得的适应功能将与这些功能形成对比 当小脑功能失调时，管理适应。 猫 范式将用于评估发生在 小脑的收购以及这两个的执行 适应行为的类型。 功能上多个单元记录 小脑皮层和核的相关区域将阐明 在两个期间，特定矢状区域内的神经元相互作用 这些自适应行为的获取和表现，强调这些行为 与学习的小脑相关特征有关的相互作用 过程。 这些发现将揭示与 学习运动行为，这是某些功能异常的基础 在小脑患者和一般机制中 在中央消融病理学后，运动功能的恢复 神经系统。