HOST RESPONSE TO HELICOBACTER PYLORI INFECTION

宿主对幽门螺杆菌感染的反应

• 批准号: 2907005
• 负责人: PELAYO none CORREA
• 金额: $ 7.15万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2907005
• 关键词: African American; Helicobacter; achlorhydria; bacteria infection mechanism; cancer risk; caucasian American; cellular immunity; chronic disease /disorder; clinical research; disease /disorder etiology; enteric bacteria; gastric mucosa; gastritis; gastrointestinal disorder diagnosis; helper T lymphocyte; host organism interaction; human subject; low socioeconomic status; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplasm /cancer immunodiagnosis; preneoplastic state; racial /ethnic difference; social class; stomach neoplasms

Gastritis due to Helicobacter Pylori is the most common chronic infection in the world today. It has been classified by IARC (WHO) as a Class I human carcinogen. Obviously only a very small portion of the infected population develops gastric cancer. This neoplasia, however, is the second most frequent in the world. In the United States, certain groups display higher risk, especially African Americans, Hispanics, Asian Americans and immigrants from Russia and Eastern Europe. This application addresses the question of different outcomes of H. Pylori infection, which in some subjects leads to gastric carcinogenesis and in others does not. The central hypothesis is that the dichotomy in outcome of the infection is driven by immunologic forces. The proposed small grant application will make it possible to conduct a feasibility study which will determine if a more definitive test of the hypothesis is possible. We will be focused on the cellular-mediated immune response studied in lymphocytes from the peripheral blood and from the gastric mucosa. Two major comparisons will be done: A) In Colombia H. pylori infected subjects living in Nari$o, at very high gastric cancer risk, will be compared with infected subjects living in the coastal city of Cartagena, at very low risk. b) In New Orleans, subjects diagnosed with multiphocal atrophic gastritis (MAG), a cancer precursor lesion, will be compared with subjects with non-atrophic gastritis (diffuse antral gastritis or DAG), which is not associated with increased gastric cancer risk. A full battery of immunologic tests will be carried out to explore if the cytokines characteristic of the T-lymphocyte helper cells responses (Th1 vs. Th2) are different in the contrasting populations. If approved, this application will make it possible to collect the material needed and complement other resources of the department of Pathology to conduct the tests in our laboratories.

幽门螺杆菌引起的胃炎是当今世界上最常见的慢性感染。 它已由IARC（WHO）分类为I类人致癌物。 显然，只有一小部分感染人群会发展出胃癌。 然而，这种肿瘤是世界第二常见的。 在美国，某些群体的风险更高，尤其是非裔美国人，西班牙裔，亚裔美国人以及来自俄罗斯和东欧的移民。 该申请解决了幽门螺杆菌感染不同结果的问题，在某些受试者中，这会导致胃癌发生，而在其他受试者中则没有。 中心假设是感染预后的二分法是由免疫学驱动的。 提出的小型赠款应用将使进行可行性研究成为可能，该研究将确定对假设的更确定性检验。 我们将专注于外周血和胃粘膜中淋巴细胞中研究的细胞介导的免疫反应。 将进行两个主要的比较：a）在哥伦比亚H.幽门螺杆菌感染的纳里$ O中，居住在Nari $ o中的受试者将与居住在沿海城市Cartagena的感染受试者进行比较，风险非常低。 b）在新奥尔良，将将诊断患有多局部萎缩性胃炎（MAG）的受试者（一种癌症前体病变）与非营养性胃炎的受试者（弥漫性肛门胃炎或DAG）进行比较，与胃癌风险增加无关。 将进行全部免疫测试，以探索T-淋巴细胞辅助细胞的细胞因子特征是否在对比群体中不同。 如果获得批准，此申请将有可能收集所需的材料并补充病理学系的其他资源，以在我们的实验室中进行测试。