YOUNG ADULT OUTCOMES OF VERY LOW BIRTHWEIGHT CHILDREN

极低出生体重儿童的成年后结局

• 批准号: 6151154
• 负责人: MAUREEN HACK
• 金额: $ 25.41万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6151154
• 关键词: academic achievement; attention deficit disorder; behavioral /social science research tag; blood pressure; body physical activity; body physical characteristic; child psychology; clinical research; cognition; human subject; interpersonal relations; juvenile delinquency; longitudinal human study; low birth weight infant human; outcomes research; parent offspring interaction; peer group; prognosis; psychological adaptation; psychomotor function; respiratory function; sibling relations; social psychology; substance abuse related disorder; young adult human (21-34)

DESCRIPTION: This proposal requests support for a four-year follow-up study of the adolescent consequences of very low birthweight (VLBW less than 1.5 Kg). A cohort of 249 LBW born in 1977-1979 was studied longitudinally at five previous times: birth, expected term date, 8 months, 2 years, and 8 years of age. Data were obtained on sociodemographic and perinatal variables at birth and on growth, disease variables and neurodevelopmental status at all subsequent time points. At 8 years of age, outcomes were compared to a regional comparison group of 363 normal birthweight (NBW) children. The proposed study will extend the longitudinal data set to 18 years of age. At this time it will also include a sibling control group. Follow up data will be gathered on growth attainment, health, psychosocial development, individual functioning and peer and family relationships. The investigators will test the following hypotheses regarding VLBW at 18 years of age compared to NBW controls and same sex and age appropriate siblings: 1) VLBW will demonstrate catch up in growth but will have lower ponderal indices and a later history of puberty onset; 2) VLBW will demonstrate significant differences in health measures -- more respiratory symptoms, lower blood pressure and poorer motor functioning; and 3) VLBW will demonstrate significantly poorer academic and psychosocial functioning, poorer perceived competence and more behavioral symptoms (which will be associated with higher levels of drug abuse and violent behavior), and poorer peer and family relationships. The investigators also hypothesize that the outcomes described in Hypothesis 3 will be worse in adolescents with subnormal cognition and from socially disadvantaged families. The data analytic plan is to examine the direct effects of VLBW on 18 year outcomes as well as the mediating and moderating influences of intervening variables which may affect this relationship. Data will be gathered from adolescents and mothers via structured interviews and questionnaires, a standardized IQ test, and growth and blood pressure measurements. Data will be merged with previously documented measures. Three types of analyses will be performed: 1) con-current comparisons of VLBW and controls; 2) longitudinal outcomes; and 3) internal comparisons between subsets of VLBW children. The plan to examine functional outcomes of VLBW adolescents as individuals and among their peers and family will provide a societal and life span perspective of the consequences of VLBW. The results have implications concerning the current aggressive neonatal care of extremely immature infants.

描述：该提案请求支持为期四年的后续研究 极低出生体重（VLBW 低于 1.5）对青少年的影响 公斤）。 对 1977 年至 1979 年出生的 249 名 LBW 进行了纵向研究 之前五次：出生、预产期、8 个月、2 年和 8 岁数。 获得了社会人口统计学和围产期数据 出生时和生长时的变量、疾病变量和神经发育变量 所有后续时间点的状态。 8岁时，结果是 与 363 名正常出生体重 (NBW) 的区域对照组相比 孩子们。 拟议的研究将纵向数据集扩展到 18 岁数。 此时它还将包括一个兄弟对照组。 将收集有关成长成就、健康、心理社会的后续数据 发展、个人功能以及同伴和家庭关系。 这 研究人员将测试以下关于 18 岁时极低出生体重的假设 与 NBW 对照以及同性别和同龄兄弟姐妹相比的年龄： 1) 极低体重儿将表现出追赶性增长，但体重较低 指标和青春期后期的发病史； 2）VLBW将演示 健康措施的显着差异——更多的呼吸道症状， 血压降低和运动功能较差； 3) VLBW 将 表现出明显较差的学业和心理社会功能， 感知能力较差，行为症状较多（这将是 与较高程度的药物滥用和暴力行为有关），以及 同伴和家庭关系较差。 研究人员还假设 假设 3 中描述的结果在青少年中会更糟 认知能力低于正常水平且来自社会弱势家庭。 数据 分析计划是检查 VLBW 对 18 年结果的直接影响 以及中介变量的中介和调节影响 这可能会影响这种关系。 数据将从青少年收集 通过结构化访谈和问卷调查，标准化智商 测试、生长和血压测量。 数据将被合并 先前记录的措施。 将执行三种类型的分析： 1) VLBW和对照的同时比较； 2）纵向结果； 3) VLBW 儿童子集之间的内部比较。 该计划旨在 检查 VLBW 青少年作为个体和群体之间的功能结果 他们的同龄人和家人将为他们提供社会和生命周期的视角 极低出生体重儿的后果。 结果对以下方面有影响： 目前对极不成熟婴儿的积极新生儿护理。