Biomedical follow-up of 1958 Birth Cohort Study members at age 60

1958 年出生队列研究成员 60 岁时的生物医学随访

基本信息

批准号：
MR/P023444/1
负责人：
Alissa Goodman
金额：
$ 324.1万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FP023444%2F1
关键词：
Biomedical follow up 1958 Birth

项目摘要

The increase in human life expectancy over the last century has been one of the greatest achievements in public health. However, it also poses new challenges in health and social care, in particular the increased burden of ill health associated with older age, including cognitive impairment and frailty. Understanding the occurrence of these ageing outcomes and their determinants has become a global research priority with considerable policy implications. Several influential studies have been established in middle- and older-aged populations in the UK and in other countries with the capacity to offer much-needed insights into these issues. It has recently become evident, however, that the processes that underlie ageing states begin much sooner in the life course than originally thought, in some cases as early as birth or preconception. It is in such studies that cover the lifespan that the UK excels. The 1958 Birth Cohort Study in the UK is the largest long-running study of this type. Its study members are approaching 60 years of age, when problems of ageing typically begin to emerge. We will therefore carry out a detailed survey which captures key domains of healthy ageing incorporating multiple dimensions of health (for example, cardiometabolic, cognitive, and physical health) combined with genetic and environmental factors that have been collected across the lifetime of the cohort. Uniquely, this new information will allow us to answer a series of important research questions of public health importance. These include the role of infection in early life in CVD, explaining why individuals remain undiagnosed or inadequately treated for CVD and diabetes, the extent to which CVD risk in early older age can be reversed by physical activity initiated in midlife, how physical function and co-ordination in childhood are related to physical function measures at age 60, and whether the duration and quality of employment over the lifetime is protective of cognitive decline. We will also be able to run a series cross-cohort comparisons, to allow us to highlight where such disease and ageing processes are changing across generations. These data will become publically available to scientists soon after collection, so providing an unparalleled resource for the scientific community to investigate a range of policy-relevant issues. This improved understanding will ultimately lead to changes in individual behaviour and improvements in public policy and professional practice that will lead to better public health and healthier longer lives.In summary, what affects health and how fast we age was originally thought to be a result of what we did as adults, such as how much we smoked, drank, exercised, and our weight, as well as our genes. Research is now beginning to show that factors in our childhood may also have an impact on later illness and ageing. Financial help from the Medical Research Council will allow us to track the health of people who were born in the 1950s in the UK as they reach 60 years of age, to show how lifelong factors affect how we age, and to recommend policies that will improve the health of the older population.

上个世纪人类预期寿命的增加一直是公共卫生中最大的成就之一。但是，这也带来了健康和社会护理方面的新挑战，尤其是与年龄较大有关的健康负担增加，包括认知障碍和脆弱。了解这些老龄化结果及其决定因素的发生已成为具有相当大的政策影响的全球研究优先事项。在英国和其他国家中，已经在中年和老年人口中建立了一些有影响力的研究，他们有能力对这些问题提供急需的见解。然而，最近显而易见的是，在人生过程中，基础衰老状态的过程比最初想象的要早，在某些情况下，早在出生或先入为主就开始。在这样的研究中，英国擅长的是寿命。 1958年在英国进行的出生队列研究是此类最大的长期研究。当衰老问题通常开始出现时，其研究成员即将接近60岁。因此，我们将进行一项详细的调查，该调查捕获健康衰老的关键领域，结合了健康的多个维度（例如，心脏代谢，认知和身体健康），并结合了整个队列一生中收集的遗传和环境因素。独特的是，这些新信息将使我们能够回答有关公共健康重要性的一系列重要研究问题。这些包括感染在CVD早期生命中的作用，解释了为什么个人无法诊断或对CVD和糖尿病的治疗不充分，而在中年开始开始的体育锻炼，在年龄较早的早期中，CVD风险在年龄较早的早期造成的程度，童年的身体功能和协调在60岁时的身体功能降低以及在60岁时的效果和质量的效果是如何相关的。我们还将能够进行一系列的横向比较，以使我们能够强调各个一代的疾病和衰老过程在哪里发生了变化。这些数据将在收集后不久就会公开向科学家公开，因此为科学界提供了无与伦比的资源来研究一系列与政策相关的问题。这种改善的理解最终将导致个人行为的变化以及公共政策和专业实践的改善，这将带来更好的公共卫生和更健康的寿命。总而言之，影响健康以及我们年龄的速度最初被认为是我们成年人所做的事情的结果，例如我们吸烟，喝酒，喝酒，锻炼，运动以及我们的体重以及我们的基因以及我们的基因。现在的研究开始表明，我们童年时期的因素也可能会影响以后的疾病和衰老。医学研究委员会的财务帮助将使我们能够跟踪1950年代在英国达到60岁的人的健康状况，以说明终身因素如何影响我们的年龄，并推荐将改善老年人口健康的政策。