PROSPECTIVE STUDY OF NUTRITION IN THE ELDERLY

老年人营养的前瞻性研究

• 批准号: 2853417
• 负责人: PHILIP J GARRY
• 金额: $ 10万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2853417
• 关键词: apolipoprotein E; clinical research; genotype; human old age (65+); human subject; iron metabolism; longitudinal human study; nutrition of aging; nutrition related tag

The New Mexico Aging Process Study (NMAPS) is a longitudinal, multidisciplinary investigation of age-relate changes in nutritional status in relation to the health and functional status of an elderly cohort. The overall hypothesis of the NMAPS is that nutrition, body composition and genetic polymorphism play key roles in the modulation of the aging process and the maintenance of health, functional ability and independence in community-dwelling elderly. This unique study is presently in its 19th year of continuous follow-up; the present application requests funds for the extension and expansion of this study for an additional 5 years. In the present renewal, we plan to focus our studies on how specific genetic polymorphisms affect serum lipids, iron and cognitive status, since all of these conditions have been linked to chronic diseases, either in a positive or negative manner. Additionally, stored serum and plasma samples collected in a recently completed population-based survey of elderly men and women in the New Mexico Elder Health Survey (NMEHS AG10941, 1993-96; P.I. Robert D. Lindeman, M.D.) will be used along with stored serum and plasma samples (-70 C) from participants in the NMAPS who have died or dropped from the study in the interim between 1980 and 1998. Data obtained from participants in the NMEHS will be compared with similar data from the NMAPS to examine differences in health status and ethnicity. The NMEHS is population based while the subjects enrolled in the NMAPS are selected on the basis of good health status. The specific aims of this continuing renewal proposal are as follows: 1) To assess genotype and gene frequencies in elderly men and women enrolled in the NMAPS and NMEHS; specifically: apolipoprotein E genotypes and genetic polymorphism's related to iron stores (Cys282Tyr and His63Asp mutations). 2) To determine associations of apolipoprotein E genotypes with serum lipid concentrations, interactive effects of estrogen replacement therapy, insulin sensitivity, fat distribution and cognitive status. Evaluate the association of the Cys282Tyr and His63Asp mutations as they relate to iron stores and diabetes.

新墨西哥州的老化过程研究（NMAP）是对与老年队列的健康和功能状况有关的纵向，多学科研究。 NMAP的总体假设是，营养，身体成分和遗传多态性在调节过程中起着关键作用，并维持健康，社区居住的老年人的健康，功能能力和独立性。 这项独特的研究目前是在其连续随访的第19年。本申请要求将资金延长和扩展为5年。 在目前的续签中，我们计划将研究集中在特定的遗传多态性上如何影响血清，铁和认知状况，因为所有这些疾病都以阳性或阴性方式与慢性疾病有关。 此外，在新墨西哥州老年人健康调查（NMEHS AG10941，1993-96; P.I. Robert D. Lindeman，M.D。）中，在最近完成的基于人群的老年男女调查中收集的血清和血浆样品将与储存的血清和血浆样本（-70 c）一起使用，这些人与参与者相互访问，这些人与参与者相互研究，这些人与参与者相互研究，这些人与参与者相互作用，这些人与参与者相互作用，这些人与参与者相互作用，这些人将与他们一起使用。 1998。将从NMEHS参与者获得的数据与NMAP的类似数据进行比较，以检查健康状况和种族的差异。 NMEHS是基于人口的，而在NMAP中注册的受试者是根据良好的健康状况选择的。该持续更新建议的具体目的如下：1）评估Nmaps和Nmehs入学的老年男女中的基因型和基因频率；具体而言：载脂蛋白E基因型和遗传多态性与铁储存有关（CYS282TYR和HIS63ASP突变）。 2）确定载脂蛋白E基因型与血清脂质浓度的关联，雌激素替代疗法的相互作用，胰岛素敏感性，脂肪分布和认知状况。 评估与铁储存和糖尿病有关的CYS282TYR和HIS63ASP突变的关联。