Investigation of the early growth response gene (Egr) 2 and 3 mediated regulatory programme in T cells

T 细胞中早期生长反应基因 (Egr) 2 和 3 介导的调控程序的研究

• 批准号: MR/N00096X/1
• 负责人: Ping Wang
• 金额: $ 61.6万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN00096X%2F1
• 关键词: Investigation; early; growth; response; gene

Our heath relies on the normal function of the immune system. The function of the immune system is uniquely regulated in such a way that it can maintain a robust attack against pathogens, such as viruses, but remain tolerant of one's own tissues. Although the function of the immune system has been extensively studied, the mechanisms which cause the immune system to mistakenly attack one's own body or to permit the persistence of certain viruses, such as HIV, in our body are still unknown. More than 80 clinically distinct autoimmune diseases result from dysregulation of the immune system. Several are well known, including rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and lupus. Others are less familiar, including autoimmune hepatitis, Sjögren's syndrome, autoimmune ear disease, and pemphigus. Equally, more than 10 chronic infectious diseases, such as HIV and hepatitis C virus infection, result from a failure of our immune system to provide protection. Collectively, these diseases afflict an estimated 5 to 8 per cent of the population in the UK and worldwide. The social and financial burdens imposed by these chronic, debilitating diseases include poor quality of life, high health care costs, and substantial loss of productivity. Recently we discovered a unique function of two molecules, Egr2 and 3, in one type of white blood cells, T cells, which is essential for preventing the immune system from attacking self-tissues while promoting immune attacks on viruses. Removal of these two molecules from T cells from mice results in severe autoimmune diseases that are similar to human lupus diseases and these mice also fail to recover from virus infection. These findings were previously unknown and have been published in leading immunological journals such as 'The Journal of Immunology', 'The Journal of Experimental Medicine' and 'Immunity'. The proposed study aims to define the mechanisms by which Egr2 and 3 prevent T cells from attacking self-tissues but enhance their anti-virus function. The findings from the proposed study would not only provide a better conceptual understanding of immunological function, but importantly provide new strategies for the development of therapies for autoimmune and chronic infectious diseases.

我们的荒地依赖于免疫系统。我们体内的某些病毒酶（例如HIB）仍然未知。 ，包括自身免疫性肝炎，Sjögren综合征，自身免疫性耳病和Pemphigus。英国和全球。对于预防攻击自我攻击的免疫力，促进对病毒的免疫攻击，来自小鼠小鼠的ECULES导致与人类狼疮疾病相似的严重自身免疫性疾病，这些小鼠也无法从病毒感染中恢复过来在领先的免疫学期刊上，人们的“杂志”的“无害杂志”是“免疫”杂志。研究不仅会更好地了解免疫局部功能的聚道型疾病。

项目成果

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

• DOI: 10.1084/jem.20160553
• 发表时间: 2017-06-05
• 期刊: The Journal of experimental medicine
• 作者: Miao T;Symonds ALJ;Singh R;Symonds JD;Ogbe A;Omodho B;Zhu B;Li S;Wang P
• 通讯作者: Wang P

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

• DOI: 10.1002/iid3.210
• 发表时间: 2018-06
• 期刊: Immunity, inflammation and disease
• 作者: Omodho B;Miao T;Symonds ALJ;Singh R;Li S;Wang P
• 通讯作者: Wang P