Sedentary behaviour in older adults: investigating a new therapeutic paradigm

老年人的久坐行为：研究新的治疗范式

• 批准号: MR/K025090/1
• 负责人: Thomas Yates
• 金额: $ 108.7万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK025090%2F1
• 关键词: Sedentary; behaviour; older; adults; investigating

Older age is associated with an increased risk of many diseases, poor physical function and frailty, cognitive decline and other forms of disability. Also, some groups such as South Asians have higher rate of disease. Research has shown that many of these factors are improved by higher levels of physical activity. However, little is known about the role of sedentary behaviour i.e., sitting time in older adults. Some research has started to show that reducing the time that you spend sitting can reduce the risk of many diseases and improve functional health. This research suggests that improvements in health may be gained by simply helping people to swop time spent sitting with time spent standing or in light-intensity walking. Older adults spend around 70% of their day sitting but little is currently known about whether reducing sitting time promotes health and wellbeing in older adults. This may be particularly relevant to older adults where fear of falls, joint pain, decreased physical function and other contraindications may limit motivation and ability to engage in much purposeful exercise. This grant is therefore going to focus on investigating the impact of sitting in older adults. The results of this research will inform larger studies and public health initiatives aimed at reducing sitting time in the future.Our research plan includes three work packages. In work package one, we will develop a method of estimating time spent sitting and in physical activity which hasn't been done before in older adults. This will be done in a laboratory where participants will complete a set of activities and we will measure the intensity of these activities. Another part of this work package is to use existing data that has been collected as part of the Health Survey for England. We will re-analyse this data to investigate how much sitting and physical activity older adults do, when and how often they do these behaviours (e.g., morning ,afternoon, evening, numbers of times in the day and how long for each time), and compare this to other age groups. We will also look at the relationship between sitting and physical activity with health and wellbeing in older adults. This data will be supplemented with data that we have collected within our department in a large population of older multi-ethnic adults. Work package two will develop a novel way of measuring sitting time which allows researchers to capture the location of where older adults spend the their time around the home/car environment and more accurately measure sitting time. This will involve a wrist worn device along with very small tags that can be attached to objects (such as chairs, tables, computers etc). We can then combine the information from both devices to measure time spent sitting but also the type of sitting behaviour and the location around the home (e.g., sofa in living room, computer in office, dining table etc). This will help researchers to develop ways to help people to reduce their sitting time. This novel method will be tested in a laboratory and also a small number of people will be asked to test it in their daily lives. Once they have done this we will ask them for feedback on perceptions of sedentary behaviour and these novel method of measuring sitting. Work package three will be a laboratory study to investigate the impact of sitting down all day (condition one), reducing sitting by standing every 30 minutes for a few minutes (condition two) and reducing sitting by slowly walking every 30 minutes for a few minutes (condition three). Participants will come into the laboratory and perform each of these conditions over a day (8am-5pm). During these conditions blood sugar, insulin, fats in the blood, mood and cognitive function will be measured. This work package will investigate how harmful sitting is for health and whether health can be improved by reducing sitting time either by standing or light walking or both.

老年与许多疾病的风险增加有关，身体机能不佳，脆弱，认知能力下降和其他形式的残疾。而且，一些南亚等人的疾病率更高。研究表明，这些因素中的许多因素都通过较高的体育锻炼来改善。但是，关于久坐行为的作用，即在老年人中坐着的时间，知之甚少。一些研究开始表明，减少您花费的时间可以降低许多疾病的风险并改善功能健康。这项研究表明，可以通过简单地帮助人们坐在坐着花费的时间或在轻度强度步行的时间里坐着时间来获得健康的改善。老年人花费大约70％的一天坐着，但目前几乎不知道减少坐姿是否可以促进老年人的健康和福祉。这可能与老年人特别相关，因为那些担心跌倒，关节痛，身体机能减少和其他禁忌症的老年人可能会限制动机和进行大量有目的的运动的能力。因此，该赠款将重点放在调查老年人坐的影响上。这项研究的结果将为旨在减少未来坐姿的大型研究和公共卫生计划提供信息。我们的研究计划包括三个工作包。在工作包中，我们将开发一种估计坐着和体育锻炼所花费的时间的方法，而这在老年人之前从未做过。这将在一个实验室中完成，参与者将完成一系列活动，我们将衡量这些活动的强度。该工作包的另一部分是使用已收集的现有数据作为英格兰健康调查的一部分。我们将重新分析这些数据，以调查老年人的坐姿和体育锻炼，何时何地进行这些行为（例如，早晨，下午，晚上，白天的数量以及每次的时间数量），并将其与其他年龄段进行比较。我们还将研究坐姿与体育锻炼与老年人健康与健康之间的关系。这些数据将补充我们在部门内收集的数据，其中大量年长的多种族成年人。工作套餐二将开发出一种新颖的测量坐姿方式，使研究人员能够捕捉老年人在家庭/汽车环境周围度过的时间的位置，并更准确地测量坐姿。这将涉及腕部磨损的设备以及可以连接到物体（例如椅子，桌子，计算机等）的非常小的标签。然后，我们可以将两种设备的信息结合在一起，以测量坐着的时间，以及坐着行为的类型以及房屋周围的位置（例如，在客厅中的沙发，办公室计算机，餐桌等）。这将帮助研究人员开发帮助人们减少坐姿的方法。这种新颖的方法将在实验室中进行测试，并将要求少数人在日常生活中对其进行测试。一旦他们做到了这一点，我们将要求他们反馈对久坐行为的看法以及这些新颖的测量坐姿。工作包三将是一项实验室研究，以调查整天坐下（条件第一）的影响，每30分钟站立每30分钟（条件二），减少坐着，并减少每30分钟慢慢步行几分钟（条件三）。参与者将进入实验室，并在一天（上午8点至下午5点）内执行这些条件。在这些条件下，将测量血糖，胰岛素，血液中的脂肪，情绪和认知功能。该工作包将调查坐姿对健康有多大的有害，以及是否可以通过站立或轻便的步行或两者两者减少坐姿来改善健康。

项目成果

Additional file 1: Figure S1. of Associations of mutually exclusive categories of physical activity and sedentary time with markers of cardiometabolic health in English adults: a cross-sectional analysis of the Health Survey for England

附加文件 1：图 S1。

• DOI: 10.6084/m9.figshare.c.3610589_d1
• 发表时间: 2016
• 作者: Bakrania K

A Novel Algorithm for Determining the Contextual Characteristics of Movement Behaviors by Combining Accelerometer Features and Wireless Beacons: Development and Implementation.

• DOI: 10.2196/mhealth.8516
• 发表时间: 2018-04-20
• 期刊: JMIR mHealth and uHealth
• 影响因子: 5
• 作者: Magistro D;Sessa S;Kingsnorth AP;Loveday A;Simeone A;Zecca M;Esliger DW
• 通讯作者: Esliger DW

FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

• DOI: 10.1136/bmj.i4707
• 发表时间: 2016-09-20
• 期刊: BMJ (Clinical research ed.)
• 作者: Livingstone KM;Celis-Morales C;Papandonatos GD;Erar B;Florez JC;Jablonski KA;Razquin C;Marti A;Heianza Y;Huang T;Sacks FM;Svendstrup M;Sui X;Church TS;Jääskeläinen T;Lindström J;Tuomilehto J;Uusitupa M;Rankinen T;Saris WH;Hansen T;Pedersen O;Astrup A;Sørensen TI;Qi L;Bray GA;Martinez-Gonzalez MA;Martinez JA;Franks PW;McCaffery JM;Lara J;Mathers JC
• 通讯作者: Mathers JC

A Novel Algorithm for Determining the Contextual Characteristics of Movement Behaviors by Combining Accelerometer Features and Wireless Beacons: Development and Implementation

通过结合加速度计功能和无线信标来确定运动行为的上下文特征的新算法：开发和实现

• DOI: 10.2196/preprints.8516
• 发表时间: 2017
• 作者: Magistro D

Associations of mutually exclusive categories of physical activity and sedentary time with markers of cardiometabolic health in English adults: a cross-sectional analysis of the Health Survey for England.

• DOI: 10.1186/s12889-016-2694-9
• 发表时间: 2016-01-12
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Bakrania K;Edwardson CL;Bodicoat DH;Esliger DW;Gill JM;Kazi A;Velayudhan L;Sinclair AJ;Sattar N;Biddle SJ;Khunti K;Davies M;Yates T
• 通讯作者: Yates T