Wellcome Trust MRC Human Inducible Pluripotent Stem Cell Initiative

Wellcome Trust MRC 人类诱导多能干细胞计划

• 批准号: MC_PC_12026
• 负责人: Fiona Watt
• 金额: $ 510.84万
• 依托单位: Wellcome Sanger Institute
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_12026
• 关键词: Wellcome; Trust; MRC; Human; Inducible

As it becomes cheaper and faster to sequence the DNA of individuals in the population we are faced with two challenges. One is to discover which aspects of the genetic variation between individuals are compatible with good health and which are linked to increased risk of specific diseases. The other is that it is not always obvious why a particular genetic mutation causes a particular disease; if we knew the answer we would be better placed to devise new ways to treat that disease. A technique that can help us meet these challenges is to make stem cells, known as induced pluripotent stem (iPS) cells, from small samples of the skin or blood of healthy and diseased individuals. By comparing the DNA of iPS cells with the way the cells behave when grown in the laboratory we can understand how variation in our DNA results in variation in cell behaviour and use this information to identify new disease mechanisms. The iPS cells and associated data that we generate will be freely available to researchers and doctors throughout the UK and will foster collaborations that will speed up the translation of research into improved diagnosis and treatment of disease.

随着对人群中个体 DNA 进行测序变得更便宜、更快捷，我们面临着两个挑战。一是发现个体之间遗传变异的哪些方面与良好健康相容，哪些方面与特定疾病的风险增加有关。另一个原因是，为什么特定的基因突变会导致特定的疾病并不总是显而易见的。如果我们知道答案，我们就能更好地设计治疗这种疾病的新方法。可以帮助我们应对这些挑战的技术是从健康和患病个体的皮肤或血液的小样本中制造干细胞，称为诱导多能干（iPS）细胞。通过将 iPS 细胞的 DNA 与实验室中生长的细胞行为方式进行比较，我们可以了解 DNA 的变化如何导致细胞行为的变化，并利用这些信息来识别新的疾病机制。我们生成的 iPS 细胞和相关数据将免费提供给英国各地的研究人员和医生，并将促进合作，加速将研究转化为改进的疾病诊断和治疗。

项目成果

Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease.

暴饮暴食和遗传风险是酒精相关肝病的决定因素。

• DOI: http://dx.10.17863/cam.102249
• 发表时间: 2023
• 作者: Ding C

Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta- Analysis

补充维生素 D 对血管功能标志物的影响：系统评价和个体参与者荟萃分析

• DOI: http://dx.10.17863/cam.27691
• 发表时间: 2018
• 作者: Beveridge L

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.

轻至中度肾功能障碍和心血管疾病：观察性和孟德尔随机分析。

• DOI: http://dx.10.17863/cam.90825
• 发表时间: 2022
• 作者: Gaziano L

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response.

对染色质和基因表达的共同遗传效应表明增强子启动在免疫反应中的作用。

• DOI: http://dx.10.1038/s41588-018-0046-7
• 发表时间: 2018
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Alasoo K

Bench to bedside: Current advances in regenerative medicine.

从工作台到床边：再生医学的最新进展。

• DOI: 10.1016/j.ceb.2018.05.006
• 发表时间: 2018-12-01
• 期刊: Current opinion in cell biology
• 影响因子: 7.5
• 作者: Gabriella Clarke;Peter Harley;Ella L Hubber;T. Manea;L. Manuelli;E. Read;F. Watt
• 通讯作者: F. Watt