Functions and therapeutic potential of vascular Orai/CRAC channels

血管Orai/CRAC通道的功能和治疗潜力

• 批准号: G1002076/1
• 负责人: David Beech
• 金额: $ 92.18万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002076%2F1
• 关键词: Functions; therapeutic; potential; vascular; Orai

Huge networks of blood vessels (vasculatures) in humans, as well as many other species, enable provision of nutrients to organs and removal of waste; much as transport systems do for cities. The blood vessels have inbuilt capacity to change (remodel) to meet altered demands or adjust in response to injury, which are important for normal physiology and survival in adverse conditions. In disease, the remodelling may be an advantage or disadvantage. In the case of cancer, tumours need to develop their own new blood vessels in order to progress beyond a small size. Therefore, a popular anti-cancer strategy is to try to cut off the tumour?s supply lines, reducing the tumour?s impact or destroying it. Therefore, knowledge of how to manipulate vascular remodelling may be used to enhance the quality of life and survival of people. We propose a project to investigate a promising approach for manipulating vascular remodelling and the perfusion capability of blood vessels, working as a partnership between an academic research group and industrial drug development group to increase efficiency and likelihood of societal benefit.

人类以及许多其他物种都有巨大的血管网络，能够为器官提供营养并清除废物；就像交通系统对城市的作用一样。血管具有内在的改变（重塑）能力，以满足变化的需求或针对损伤进行调整，这对于正常生理和在不利条件下的生存非常重要。在疾病中，重塑可能是有利的，也可能是不利的。就癌症而言，肿瘤需要发育出自己的新血管才能发展得比小尺寸更大。因此，一种流行的抗癌策略是试图切断肿瘤的供应线，减少肿瘤的影响或摧毁它。因此，如何操纵血管重塑的知识可用于提高人们的生活质量和生存率。我们提出了一个项目，研究一种有前途的操纵血管重塑和血管灌注能力的方法，作为学术研究小组和工业药物开发小组之间的合作伙伴关系，以提高效率和社会效益的可能性。