FUNCTION OF PLASMA MEMBRANE ATP CHANNEL PROTEINS

质膜 ATP 通道蛋白的功能

• 批准号: 5201328
• 负责人: E ABRAHAM
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201328
• 关键词: adenosine triphosphate; carcinoma; cystic fibrosis; insulin; membrane channels; membrane proteins; membrane transport proteins; multidrug resistance; receptor; sulfur

Members of the family of integral membrane proteins referred to as the ABC (ATP binding cassette) membrane proteins have been shown to us by function as ATP channels in some of our recent investigations. In particular MDR (multidrug resistance), responsible for drug resistance in cancer, and CFTR (cystic fibrosis transmembrane conductance regulator), the protein which when mutated leads to the genetic disease Cystic Fibrosis, are important members of this family. They both function as ATP channels transporting intracellular ATP to the cell surface and extracellular space. We have ongoing studies that define further membranes of this ATP transporting family to include the MRP (multidrug resistance-associated protein), responsible for some non-MDR drug resistance in cancer and SUR (sulfonyl urea receptor) responsible for triggering release of insulin.

整合膜蛋白家族的成员，称为 ABC （ATP结合盒）膜蛋白的功能已向我们展示 作为我们最近的一些调查中的 ATP 通道。 特别是耐多药 （多重耐药性），负责癌症的耐药性，以及 CFTR（囊性纤维化跨膜电导调节因子），蛋白质 当突变时会导致遗传病囊性纤维化， 这个家庭的重要成员。 它们都充当 ATP 通道 将细胞内的 ATP 转运至细胞表面和细胞外 空间。 我们正在进行研究，进一步定义该 ATP 的膜 运输家族包括MRP（多药耐药相关 蛋白），导致癌症和 SUR 中的一些非 MDR 耐药性 （磺酰脲受体）负责触发胰岛素的释放。