STUDY OF SURGERY AND PHOTODYNAMIC THERAPY FOR INTRAPERITONEAL SARCOMAS

腹膜内肉瘤的手术和光动力治疗研究

• 批准号: 3752342
• 负责人: E ABRAHAM
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752342
• 关键词: clinical trials; combination cancer therapy; human subject; human therapy evaluation; neoplasm /cancer photoradiation therapy; neoplasm /cancer relapse /recurrence; neoplasm /cancer surgery; peritoneum neoplasm; photosensitizing agents; porphyrins; radiation therapy dosage; sarcoma

Visceral sarcomas frequently develop multi-focal involvement of the peritoneal cavity. Similarly patients with retroperitoneal sarcomas can also develop multi-focal sarcoma of the peritoneal cavity. There's no effective treatment strategy for either of these problems. In a prior study (Z0l CM 06393-02 RO, Study of Surgery and Photodynamic Therapy for Intraperitoneal Malignancies), we developed the technique and defined the maximum tolerated dose of photodynamic therapy that could be delivered to the peritoneal surface. As a natural extension of that prior study, we are moving forward with this Phase II Study of Resection and Intraoperative Photodynamic Therapy for Intraperitoneal Sarcomatosis or Recurrent Retroperitoneal Sarcomas. Patients receive the dihematoporphyrin ethers photosensitizer 2.5 mg/kg 48 hours prior to a surgical procedure which involves surgical removal of tumor and intraoperative light delivery for photodynamic effect to the entire peritoneal surface.

内脏肉瘤经常出现多灶性累及 腹膜腔。 同样，腹膜后肉瘤患者也可以 还可形成腹膜腔多灶性肉瘤。 没有 针对这些问题的有效治疗策略。 在之前的 研究（Z0l CM 06393-02 RO，手术和光动力疗法研究 腹膜内恶性肿瘤），我们开发了该技术并定义了 光动力治疗的最大耐受剂量 腹膜表面。作为先前研究的自然延伸，我们 推进切除和术中的二期研究 腹膜内肉瘤病或复发性光动力疗法 腹膜后肉瘤。 患者接受二血卟啉醚 手术前 48 小时使用光敏剂 2.5 mg/kg 包括手术切除肿瘤和术中光传输 对整个腹膜表面产生光动力效应。