EVALUATION OF NEURAL IMPLANTATION

神经植入的评估

• 批准号: 3670846
• 负责人: Paul J Reier
• 金额: $ 7.66万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-28 至 1990-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3670846
• 关键词: Chordata; disease /disorder model; electron microscopy; electrophysiology; embryo /fetus; glia; model design /development; neoplasm /cancer transplantation; nervous system regeneration; nervous system transplantation; neuroblastoma; spinal cord injury; suspensions

The object is to evaluate the extent to which implanted neural tissues will repair injury to the contused spinal cord. Implants will be either cellular suspensions or whole segments of fetal cord. Mild and severe contusion models will be evaluated using morphological, physiological, and behavioral parameters for both types of implant. The extent of repair or connectivity between implants and host will be investigated with electron microscopy and electrophysiology. These findings will be correlated to observed functional status.

目的是评估植入神经的程度 组织将修复挫伤的脊髓损伤。 植入物 要么是细胞悬浮液，要么是胎儿的整个片段 绳索。 轻度和重度挫伤模型将使用以下方法进行评估 两者的形态、生理和行为参数 植入物的类型。 修复或连接的程度 将用电子显微镜研究植入物和宿主 和电生理学。 这些发现将与 观察功能状态。