Selective targeting of synapses to specific dendritic locations and their modulation by voltage-gated channels

突触选择性靶向特定树突位置及其通过电压门控通道的调制

• 批准号: G1000629/1
• 负责人: Alex Thomson
• 金额: $ 190.85万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000629%2F1
• 关键词: Selective; targeting; synapses; specific; dendritic

The neocortex is the part of the brain that has expanded most dramatically in size and complexity in parallel with the development of human intellectual abilities. Here, countless thousands of pieces of information about our own bodies and the world around us are integrated and processed to generate perceptions and memories and to initiate appropriate responses. These pieces of information arrive from all over the nervous system as electrical signals. These electrical signals are transferred from one nerve cell, or neurone, to another via tiny chemical signals that in turn generate electrical and chemical events in each follower neurone. The receiving neurones are often very complex, in their shapes and in their electrical and chemical properties. Each one is made up of many different compartments into which information can be channelled. The properties of these different compartments, the way that events in them interact with events in other compartments and how they work together to transform the many different pieces of information that constantly bombard each neurone, into the output of that cell, is the subject of this project. We focus particularly on properties that are affected in neurological diseases such as the several different types of epilepsy, in some cases as the possible cause, in others as the brain?s response to another change or insult.

新皮质是大脑中随着人类智力发展而在尺寸和复杂性上急剧扩张的部分。在这里，无数关于我们自己的身体和周围世界的信息被整合和处理，以产生感知和记忆并启动适当的反应。这些信息以电信号的形式来自整个神经系统。这些电信号通过微小的化学信号从一个神经细胞或神经元转移到另一个神经细胞或神经元，进而在每个跟随神经元中产生电和化学事件。接收神经元的形状、电学和化学特性通常非常复杂。每一个都由许多不同的隔间组成，信息可以被引导到这些隔间中。这些不同隔室的属性、其中的事件与其他隔室中的事件相互作用的方式以及它们如何协同工作将不断轰炸每个神经元的许多不同信息片段转换为该细胞的输出，是本次研究的主题项目。我们特别关注神经系统疾病（例如几种不同类型的癫痫）中受影响的特性，在某些情况下作为可能的原因，在其他情况下作为大脑对另一种变化或侮辱的反应。