Mitochondrial ATP synthase: cellular power generator, determinant of mitochondrial cristae formation, a site linked to human diseases

线粒体 ATP 合酶：细胞发电器、线粒体嵴形成的决定因素、与人类疾病相关的位点

• 批准号: MC_UU_00028/9
• 负责人: John Walker
• 金额: $ 49.69万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00028%2F9
• 关键词: Mitochondrial; ATP; synthase; cellular; power

Energy from the sun is entrapped by photosynthesis and stored in high energy compounds that we consume in food. The energy is released by controlled burning in the mitochondria in the cells of our bodies, and stored in the high energy compound adenosine triphosphate, ATP, the fuel of biology. ATP is made in the mitochondria inside our cells. They are “power stations” full of millions of molecular turbines, the ATP synthases that rotate like man-made turbines and churn out ATP in massive quantities.We understand how these molecular turbines work, and how rotation is generated. Now we want to understand how the activity of the mammalian enzyme is regulated, how it is put together from nineteen individual constituent proteins, and the impact on the ultrastructure of the cristae of removing individual subunits.

来自太阳的能量是通过光合作用的，并储存在我们在食物中消耗的高能量化合物中。能量是通过在我们身体细胞中线粒体中受控燃烧释放的，并存储在生物学燃料的高能化合物三磷酸腺苷中。 ATP是在我们细胞内的线粒体中制造的。它们是充满数百万分子涡轮机的“动力站”，它们像人造涡轮机一样旋转并以大量数量旋转ATP。我们了解这些分子涡轮机的工作原理以及如何产生旋转。现在，我们想了解如何调节哺乳动物酶的活性，如何将其从19个单个构造蛋白中放在一起，以及对去除单个亚基的CRISTAE的超微结构的影响。