Genome-wide analysis of combinatorial cis-regulatory control of early blood progenitor cells

早期血液祖细胞顺式调控组合控制的全基因组分析

• 批准号: G0900951/1
• 负责人: Berthold Gottgens
• 金额: $ 61.89万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900951%2F1
• 关键词: Genome; wide; analysis; combinatorial; cis

Blood stem cells provide the constant supply of new blood cells throughout a person?s lifetime. Their transcriptional regulation, i.e. the fine tuning of which genes should be active at any given time, is critical for their normal function. Moreover, a large number of leukaemias arise, when this fine balance of gene activities is disturbed. However, very little is known about the molecular mechanisms responsible for setting appropriate gene activities although it is clear that they must be controlled by networks of transcription factors. Transcription factors are genes responsible for controlling the activity of other genes. This proposal aims to discover how key regulators of normal blood stem cells are integrated into the wider blood stem cell regulatory networks. This will lay the foundation for future studies aiming to identify how perturbation of specific genes causes leukaemia.

造血干细胞在人的一生中持续提供新的血细胞。它们的转录调节，即在任何给定时间微调哪些基因应该活跃，对于它们的正常功能至关重要。此外，当基因活性的这种良好平衡被破坏时，就会出现大量白血病。然而，人们对负责设定适当基因活性的分子机制知之甚少，尽管很明显它们必须受到转录因子网络的控制。转录因子是负责控制其他基因活性的基因。该提案旨在发现正常血液干细胞的关键调节因子如何整合到更广泛的血液干细胞调节网络中。这将为未来的研究奠定基础，旨在确定特定基因的扰动如何导致白血病。