Computational Genomics Analysis and Training programme (CGAT)

计算基因组学分析和培训计划（CGAT）

• 批准号: MC_PC_15065
• 负责人: Douglas Higgs
• 金额: $ 108.82万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_15065
• 关键词: Computational; Genomics; Analysis; Training; programme

CGAT's mission will be to reveal the significance of high-throughput sequence in health and disease, whilst providing training opportunities for pre- and post-doctoral scientists. The Programme will provide access to genome analysis for those UK biologists and clinicians who are less used to managing, manipulating and analysing extremely large sequence data sets. The Strategic Programme will aim both to fulfil the promise of high-throughput genome data in answering the most important questions in genetics and human disease, and to train a new generation of genomics researchers.

CGAT 的使命是揭示高通量序列在健康和疾病中的重要性，同时为博士前和博士后科学家提供培训机会。该计划将为那些不太习惯管理、操作和分析极大序列数据集的英国生物学家和临床医生提供基因组分析的机会。该战略计划的目标是实现高通量基因组数据回答遗传学和人类疾病中最重要问题的承诺，并培训新一代基因组学研究人员。

项目成果

Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial.

• DOI: 10.1016/j.ebiom.2018.04.010
• 发表时间: 2018-05
• 期刊: EBioMedicine
• 影响因子: 11.1
• 作者: Berlanga-Taylor AJ;Plant K;Dahl A;Lau E;Hill M;Sims D;Heger A;Emberson J;Armitage J;Clarke R;Knight JC
• 通讯作者: Knight JC

Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations.

• DOI: 10.1186/s13059-018-1422-4
• 发表时间: 2018-04-10
• 期刊: Genome biology
• 影响因子: 12.3
• 作者: Cartier J;Smith T;Thomson JP;Rose CM;Khulan B;Heger A;Meehan RR;Drake AJ
• 通讯作者: Drake AJ

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.

• DOI: 10.1093/brain/awx358
• 发表时间: 2018-03-01
• 期刊: Brain : a journal of neurology
• 作者: Fry AE;Fawcett KA;Zelnik N;Yuan H;Thompson BAN;Shemer-Meiri L;Cushion TD;Mugalaasi H;Sims D;Stoodley N;Chung SK;Rees MI;Patel CV;Brueton LA;Layet V;Giuliano F;Kerr MP;Banne E;Meiner V;Lerman-Sagie T;Helbig KL;Kofman LH;Knight KM;Chen W;Kannan V;Hu C;Kusumoto H;Zhang J;Swanger SA;Shaulsky GH;Mirzaa GM;Muir AM;Mefford HC;Dobyns WB;Mackenzie AB;Mullins JGL;Lemke JR;Bahi-Buisson N;Traynelis SF;Iago HF;Pilz DT
• 通讯作者: Pilz DT

Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets.

• DOI: 10.1038/s41467-018-07329-0
• 发表时间: 2018-11-19
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Aulicino A;Rue-Albrecht KC;Preciado-Llanes L;Napolitani G;Ashley N;Cribbs A;Koth J;Lagerholm BC;Ambrose T;Gordon MA;Sims D;Simmons A
• 通讯作者: Simmons A