PHARMACOLOGY OF MEMORY AND HABIT FORMATION

记忆和习惯形成的药理学

• 批准号: 4696441
• 负责人: T G AIGNER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696441
• 关键词: Alzheimer's disease; aging; anticholinergic agent; brain mapping; choline inhibitor; cholinergic agents; experimental brain lesion; habits; memory disorders; molecular psychobiology; neuroanatomy; neuropsychology; neurotoxins; physostigmine; psychopharmacology; psychophysiology; reinforcer; scopolamine

Evidence from patients with Alzheimer's disease suggests that the basal forebrain cholinergic system plays an important role in memory functioning. In support of this view, it was found that lesions of the basal forebrain in monkeys produce impairment in recognition memory and altered sensitivity to the effects of drugs that act on memory. Our results in mormal monkeys show that compounds that interfere with cholinergic mechanisms, such as the anticholinergic agent scopolamine, produce impairments in recognition memory, wherea thosee compounds that enhance cholinergic activity, such as physostigmine, improve recognition memory. In addition, our results suggest that the anterograde effects of scopolamine on memory may be greater than its retrograde effects, implying an influence on storage rather than retrieval. In a separate study, we found that THC, the active ingredient of marijuana, impairs recognition memory but is without effect on habit formation even in high doses, a dissociation implicating the limbic system as the site of action of this drug.

来自阿尔茨海默病患者的证据表明，基础 前脑胆碱能系统在记忆中起着重要作用 发挥作用。 为了支持这一观点，研究发现， 猴子的基底前脑会导致认知记忆障碍 改变对作用于记忆的药物的敏感性。 我们的 对正常猴子的研究结果表明，干扰化合物 胆碱能机制，例如抗胆碱能药物东莨菪碱， 产生识别记忆障碍，而这些复合物 增强胆碱能活性，如毒扁豆碱，提高识别能力 记忆。 此外，我们的结果表明，顺行效应 东莨菪碱对记忆的影响可能大于其逆行作用，这意味着 对存储而不是检索的影响。 在一项单独的研究中，我们 发现大麻的活性成分 THC 会损害识别能力 记忆力，但即使在高剂量下也不影响习惯的形成， 解离意味着边缘系统是这种作用的场所 药品。