PHARMACOLOGY OF MEMORY AND HABIT FORMATION

记忆和习惯形成的药理学

• 批准号: 3968509
• 负责人: T G AIGNER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968509
• 关键词: Alzheimer's disease; aging; anticholinergic agent; basal ganglia; brain mapping; cerebral cortex; choline inhibitor; cholinergic agents; experimental brain lesion; habits; limbic system; memory; memory disorders; molecular psychobiology; neuroanatomy; neuropsychology; neurotoxins; physostigmine; psychobiology; psychopharmacology; reinforcer; scopolamine

Evidence from patients with Alzheimer's disease suggest that the basal forebrain cholinergic system plays an important role in memory functioning. Our resuls from studies in normal monkeys show that compounds that interfere with cholinergic mechanisms, such as the cholinergic receptor blocker scopolamine, produce impairments in recognition memory. In addition, our results suggest that the effects of scopolamine are mainly anterograde, implying an action on storage rather than retrieval. In a separate study on habit formation, we administered the dopaminergic neurotoxin MPTP. This compound failed to impair learning at doses that did not disrupt motor function. Based on previous results suggesting that THC may be exerting its effects through an action on the limbic system, we administered this drug to monkeys performing spatial reversal, a task known to be sensitive to hippocampal damage. Doses of THC that impaired recognition memory did not affect performace on this task.

来自阿尔茨海默病患者的证据表明，基础 前脑胆碱能系统在记忆中起着重要作用 发挥作用。 我们对正常猴子的研究结果表明，化合物 干扰胆碱能机制，例如胆碱能 受体阻滞剂东莨菪碱会损害识别记忆。 此外，我们的结果表明东莨菪碱的作用主要是 顺行，意味着存储而不是检索的动作。 在一个 关于习惯形成的单独研究，我们施用多巴胺能药物 神经毒素MPTP。 这种化合物在一定剂量下并未损害学习能力 不扰乱运动功能。 根据之前的结果表明 THC 可能是通过对边缘系统的作用来发挥其作用，我们 将这种药物给予猴子进行空间逆转，这是一项已知的任务 对海马损伤敏感。 THC 损害的剂量 识别记忆不会影响这项任务的表现。