Mechanisms of autophagy regulation by the Fat/Hippo pathway

Fat/Hippo途径调控自噬的机制

• 批准号: G1002186/1
• 负责人: Manolis Fanto
• 金额: $ 63.53万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002186%2F1
• 关键词: Mechanisms; autophagy; regulation; Fat; Hippo

Neurodegenerative diseases are currently one of the top medical priorities. It is essential to understand the mechanisms through which the nerve cells (neurons) degenerate, to be able to design advanced therapies for protecting the cells. The process of autophagy, self-digestion, is of vital importance for human health in ageing and neurodgeneration. Autophagy is known to help neurons in keeping healthy through degradation of old and not functional cell components. We have discovered that new group of genes, acting in a pathway (the Fat/Hippo pathway), which is best known for its effects on cancer, is also essential for correct autophagy and neuronal health. We now wish to investigate the mechanism through which the Fat/Hippo pathway affects autophagy, so that new intelligent approaches can be designed for alleviating neurodegeneration by modulating the activity of this pathway.

神经退行性疾病目前是最重要的医疗优先事项之一。必须了解神经细胞（神经元）退化的机制，以设计用于保护细胞的先进疗法。自噬，自消化的过程对于衰老和神经变成中的人类健康至关重要。众所周知，自噬可帮助神经元通过降解旧而非功能性细胞成分来保持健康。我们已经发现，在途径（脂肪/河马途径）中起作用的新基因以其对癌症的影响而闻名，这对于正确的自噬和神经元健康也至关重要。我们现在希望研究脂肪/河马途径影响自噬的机制，以便可以通过调节该途径的活动来设计新的智能方法来减轻神经变性。