Forebrain development: From neural plate to cortical specification

前脑发育：从神经板到皮质规范

• 批准号: G0901525/1
• 负责人: Corinne Houart
• 金额: $ 175.31万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901525%2F1
• 关键词: Forebrain; development; neural; plate; cortical

The most complicated part of our brain is called the forebrain and forms the cerebral hemispheres. It develops from a very simple group of cells in the embryo and the events that transform the simple structure into the complex human cerebral hemispheres are not well understood. However, when one or many of these events are not taking place, it leads to mild or severe mental retardations. Understanding what these events are and how they shape our brain is therefore very important. This programme of research aims to identify the key events that lead to forebrain formation in vertebrates. It also seeks to discover the particular steps that create the complexity inherent to our mammalian brain. Understanding these steps will show new ways to approach mental retardation and give new tools for stem cell regenerative therapies.

我们大脑中最复杂的部分称为前脑，形成大脑半球。它是由胚胎中非常简单的细胞组发展出来的，而将简单结构转化为复杂的人脑半球的事件尚不清楚。但是，当其中一个或多个事件没有发生时，它会导致轻度或严重的智力低下。因此，了解这些事件是什么以及它们如何塑造我们的大脑非常重要。该研究计划旨在确定导致脊椎动物前脑形成的关键事件。它还试图发现产生哺乳动物大脑固有的复杂性的特定步骤。了解这些步骤将展示新的方法来处理智力障碍，并为干细胞再生疗法提供新的工具。