The Paediatric-Onset Inflammatory Bowel Disease Cohort and Treatment Study (PICTS)

儿科发病炎症性肠病队列和治疗研究 (PICTS)

• 批准号: G0800675/1
• 负责人: David Wilson
• 金额: $ 103.87万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800675%2F1
• 关键词: Paediatric; Onset; Inflammatory; Bowel; Disease

Inflammatory bowel disease (IBD) is a common problem in children and teenagers, with significant embarrassing symptoms, effects on growth and development, and interference with school progress, family and social life. There have been few successful research trials of therapies in childhood IBD, so we draw conclusions from studies in adults with IBD, where the issues can be different. Throughout Scotland, many children and teenagers (more than 450) have already joined our research study into the causes (in terms of genetic makeup and triggers in the environment) of IBD. This group is called a cohort, and our studies have been very successful in scientific terms to date. Although we have studied all potentially important genes that may have a role in the cause of IBD, none have been shown to have a major role ? the responsible genetic causes have yet to be found! We are increasing the numbers of Scottish children and young people in the cohort, which will help identify more potential genetic and environmental causes. We also wish to perform trials of therapies which will answer key questions such as what is the best treatment?, what side effects can occur? With a larger group, we can also show the expected course of some of the rarer forms of childhood IBD, such as oral Crohn?s disease, perianal-only Crohn?s disease, and ulcerative colitis of only the rectum, which have been poorly studied in childhood to date.

炎症性肠病（IBD）是儿童和青少年的常见问题，具有显着的令人尴尬的症状，影响生长发育，并干扰学校进步、家庭和社交生活。儿童 IBD 疗法的成功研究试验很少，因此我们从成人 IBD 的研究中得出结论，其中的问题可能有所不同。在整个苏格兰，许多儿童和青少年（超过 450 名）已经加入了我们对 IBD 病因（就基因组成和环境触发因素而言）的研究。这个群体被称为队列，迄今为止，我们的研究在科学方面非常成功。尽管我们已经研究了所有可能在 IBD 病因中发挥作用的潜在重要基因，但没有一个基因被证明具有主要作用？尚未找到负责任的遗传原因！我们正在增加该队列中苏格兰儿童和年轻人的数量，这将有助于识别更多潜在的遗传和环境原因。我们还希望进行治疗试验，以回答关键问题，例如什么是最好的治疗方法？可能会出现什么副作用？通过更大的群体，我们还可以显示一些较罕见的儿童 IBD 形式的预期病程，例如口腔克罗恩病、仅肛周克罗恩病和仅直肠的溃疡性结肠炎，这些疾病的治疗效果不佳从小就学习至今。