NIMH-CRB PSYCHOBIOLOGY OF DEPRESSION PROGRAM-BIO (HUMAN)

NIMH-CRB 抑郁症心理学生物学项目-BIO（人类）

• 批准号: 3553869
• 负责人: MARTIN M KATZ
• 金额: $ 4.83万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-10-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553869
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; amitriptyline; antidepressants; behavior prediction; behavior test; blood chemistry; case history; cerebrospinal fluid; circadian rhythms; cooperative study; cortisol; dexamethasone; disease /disorder classification; epinephrine; homovanillate; hormone regulation /control mechanism; human subject; human therapy evaluation; hydroxyindoleacetate; hypoglycemia; imipramine; lithium; mental disorder chemotherapy; mental disorder diagnosis; neuroendocrine system; neurotransmitter metabolism; norepinephrine; normetanephrine; nutrition related tag; pharmacokinetics; pituitary adrenal axis; psychophysiology; psychosomatic disorders; serotonin; sleep disorders; suicide; urinalysis; videotape /videodisc

Prior research strongly suggests that patients with affective disorders have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, NIMH, these findings were reviewed and some of the factors which were impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, the NIMH sponsored the development of a multiresearch center, collaborative approach to the study of the psychobiology of affective disorders. In this collaborative program, underway for several years, the major objectives have been the testing of a wide range of hypotheses which implicate neurochemistry in the etiology and maintenance of the affective disorders. In order to accomplish this, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient both before and during treatment; (b) obtaining a large number of patients and comparison subjects; and (c) the use across centers of standardized diagnostic categories and behavioral methodologies. During the preceding grant period the data have been consolidated and data analysis has begun. Preliminary results have been reported and a range of studies are in progress. The specific aim of this proposal is the continuation of the testing of earlier, as well as current, hypotheses related to the behavioral and physiological pathology, as well as to treatment responsivity which may characterize depressed patients and differentiate them from healthy subjects.

先前的研究强烈表明患有情感障碍的患者 一种或多种神经生物学功能异常 系统。 在 NIMH 临床研究分会召开的一次会议上， 对这些发现进行了审查，并对一些阻碍的因素进行了审查 朝着更全面、更综合地看待机构运作的方向迈进 躁狂症或抑郁症患者的神经生物学系统 确定。 因此，NIMH 资助开发了 多研究中心，合作研究的方法 情感障碍的心理生物学。 在这个合作计划中， 多年来，主要目标是测试 广泛的假设涉及神经化学的病因学和 维持情感障碍。 为了实现这一目标， 重点是：(a) 评估若干机构的运作情况 同一患者之前和之后的不同类型的生物系统 治疗期间； (b) 获取大量患者并进行比较 科目； (c) 跨中心使用标准化诊断 类别和行为方法。 在上一个补助期内 数据已经合并，数据分析已经开始。 初步的 结果已经报告，一系列研究正在进行中。 这 该提案的具体目标是继续测试 早期以及当前与行为和行为相关的假设 生理病理学以及治疗反应可能 描述抑郁症患者的特征并将他们与健康人区分开来 科目。