NIMH-CRB PSYCHOBIOLOGY DEPRESSION PROGRAM-BIO

NIMH-CRB 心理生物学抑郁项目-BIO

• 批准号: 3383914
• 负责人: MARTIN M KATZ
• 金额: $ 9.96万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3383914
• 关键词: antidepressants; anxiety; bipolar depression; catecholamines; disease /disorder classification; drug metabolism; human therapy evaluation; mental disorder chemotherapy; neurobiology; neurochemistry; neuroendocrine system; neurotransmitter metabolism; psychobiology; psychopharmacology

The major aim this sex-center collaborative study was to test hypotheses which implicate neurobiological mechanisms in the etiology and maintenance of the affective disorders. The collaborative approach was developed in order to provide a consortium of investigators having expertise in diverse disciplines to design and conduct the research. The study utilized uniform diagnostic criteria and behavioral methods, so as to assess the functioning of multiple biological systems in the same subjects. It provided for assessment during a baseline drug-free period and after four weeks of anti-depressant drug treatment. This collaborative effort makes it possible to test earlier and current hypotheses, and to examine interactions across and among biological systems and behavior. All data analysis for the initial phase of hypothesis testing has been essentially completed. This grant application represents a request for a final period of support during which the second phase of the testing of hypotheses which involve two or more biological systems and behavior, will be brought to a conclusion.

这项性中心合作研究的主要目的是测试 涉及神经生物学机制的假设 情感障碍的病因和维持。 这 开发协作方法是为了提供 具有不同学科专业知识的研究人员联盟 设计并进行研究。 该研究使用制服 诊断标准和行为方法，以评估 同一受试者中多个生物系统的功能。 它 在基线无毒期间进行评估，并且 经过四个星期的抗抑郁药物治疗。 这 协作努力使测试早期和当前成为可能 假设，并检验之间的相互作用 生物系统和行为。 所有数据分析为初始 假设检验阶段已基本完成。 这 赠款申请代表对最后期限支持的请求 在此期间，假设检验的第二阶段 涉及两个或多个生物系统和行为，将是 得出了结论。