TREATMENT OF IMPAIRED GLUCOSE TOLERANCE IN MALMOHUS COUNTY, SWEDEN

瑞典马尔默胡斯县葡萄糖耐量受损的治疗

• 批准号: 3941154
• 负责人: W C KNOWLER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941154
• 关键词: Scandinavian country; World Health Organization; blood vessel disorder; glucose metabolism; glucose tolerance test; glycosuria; human age group; human mortality; human subject; sex

Mortality according to glucose tolerance was studied to determine the prognosis of impaired glucose tolerance. In 1962-65, 228, 833 subjects were screened for glycosuria. Of 2477 with glycosuria, 2180 were given oral glucose tolerance tests and grouped according to normal tolerance, impaired glucose tolerance, or diabetes by World Health Organization criteria. Among subjects at least 25 years old with normal tolerance, impaired glucose tolerance, or diabetes, age-sex-adjusted mortality through 1983 was 39+2, 49+4, and 71+4 deaths/1000 person-years (+ standard error) for all causes (p less than 001 for difference in 3 groups), and 24+2, 25+3, nd 40+3 for vascular causes (cardiovascular, cerebrovascular, or renal disease) (p less than 001). 206 men with abnormal tolerance by local, but not World Health Organization, criteria were randomly assigned to diet with tolbutamide, diet only, or no treatment, which was continued through 1975. Age- adjusted all-cause mortality through 1983 did not differ significantly among treatment groups (34+9, 52+10, 45+19), but vascular mortality was 10+5, 31+8, and 38+19 in those assigned to tolbutamide, diet only, or no treatment (p less than 05). Thus, compared with persons with normal tolerance, diabetic subjects had higher all-cause and vascular mortality, and those with impaired glucose tolerance had higher all-cause but similar vascular mortality. Treatment of abnormal glucose tolerance apparently reduced vascular but not total mortality.

根据葡萄糖耐受性的死亡率来确定 葡萄糖耐受性受损的预后。 在1962-65、228、833 对受试者进行糖尿病筛查。 在2477的糖尿中， 对2180进行了口服葡萄糖耐量测试并分组 根据正常耐受性，葡萄糖耐量受损或 世界卫生组织标准的糖尿病。 在受试者中 至少25岁，具有正常耐受性，葡萄糖受损 耐受性或糖尿病，直到1983年，年龄性别调整的死亡率 为39+2、49+4和71+4死亡/1000人年（+标准 所有原因的错误）（p小于001的3组差异）， 和24+2，25+3，nd 40+3用于血管原因（心血管， 脑血管或肾脏疾病（P小于001）。 206男人 当地但世界卫生组织的异常容忍度异常， 标准随机分配给饮食，饮食，饮食 仅或没有治疗，一直持续到1975年。年龄 - 1983年调整后的全因死亡率没有差异 在治疗组中显着（34+9，52+10，45+19），但 血管死亡率为10+5、31+8和38+19 TOLBUTAMIDE，仅饮食或不治疗（P小于05）。 因此， 与具有正常耐受性的人相比 具有更高的全因和血管死亡率，以及 受损的葡萄糖耐受性较高，但类似 血管死亡率。 治疗异常葡萄糖耐受性 显然降低了血管，但不是总死亡率。