EPIDEMIOLOGY OF COMPLICATIONS OF NON-INSULIN-DEPENDENT DIABETES

非胰岛素依赖型糖尿病并发症的流行病学

• 批准号: 3855458
• 负责人: W C KNOWLER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3855458
• 关键词: Native Americans; albuminuria; amputation; blood chemistry; chronic renal failure; coronary disorder; creatinine; diabetes mellitus genetics; diabetic angiopathy; diabetic cataract; diabetic nephropathy; diabetic retinopathy; disease /disorder proneness /risk; electrocardiography; epidemiology; eye fundus photography; human morbidity; human mortality; longitudinal human study; medical complication; noninsulin dependent diabetes mellitus; peripheral blood vessel disorder; urinalysis

The purpose of the project is to determine the incidence rates, rates of progression, and risk factors for the chronic complications of NIDDM. The study is conducted in the Pima Indians of the Gila River Indian community, who have participated in a longitudinal epidemiologic study since 1965 (see project Z01 DK 69000). Risk factors for the major complications of diabetes, retinopathy, nephropathy, coronary artery disease, and peripheral vascular disease are determined by longitudinal followup of diabetic subjects. Methods of ascertainment of these complications include fundus photography, measurement of urine albumin and serum creatinine concentrations, electrocardiography, and documentation of lower extremity amputations. These complications are responsible for the major morbidity and excessive mortality associated with diabetes in this population. The incidence rates of severe complications such as end stage renal disease, cataract requiring surgical treatment, and lower extremity amputations are as high among diabetic Pimas as reported anywhere else in the world. Diabetic nephropathy is the leading cause of deaths among diabetic Pimas. Late stages of nephropathy can be predicted by minor abnormalities of urinary albumin excretion early in the course of the disease and show strong familial aggregation suggesting a genetic susceptibility to nephropathy as well as to diabetes.

该项目的目的是确定发病率，费率 NIDDM的慢性并发症的进展和危险因素。 该研究是在吉拉河印第安人的皮马印第安人进行的 社区，参加了纵向流行病学研究 自1965年以来（请参阅项目Z01 DK 69000）。 糖尿病，视网膜病的主要并发症的危险因素， 肾病，冠状动脉疾病和周围血管疾病 由糖尿病患者的纵向随访确定。 方法 确定这些并发症的问题包括底眼摄影， 测量尿白蛋白和血清肌酐浓度， 心电图和下肢截肢的记录。 这些并发症是主要的发病率和 该人群中与糖尿病有关的过度死亡率。 这 严重并发症的发病率，例如末期肾脏疾病， 需要手术治疗和下肢截肢的白内障 在糖尿病PIMA中的高度与报道的其他任何地方 世界。 糖尿病性肾病是死亡的主要原因 糖尿病PIMA。 肾病的晚期可以通过未成年人预测 尿白蛋白排泄的异常 疾病并显示强大的家族聚集表明遗传 对肾病和糖尿病的敏感性。