PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES

生物大分子物理化学

• 批准号: 3937297
• 负责人: M S LEWIS
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3937297
• 关键词: Macaca; analytical ultracentrifugation; blood coagulation; fibrin stabilizing factor; fibrinogen; fibrinolysis; glycoproteins; macromolecule; mathematical model; molecular biology; molecular size; molecular weight; plasminogen; protein structure function; thermodynamics

The purpose of this project is to study the physical properties of a wide variety of biological macromolecules with the goal of correlating these properties to the structure and function of the macromolecules. The emphasis is on the thermodynamics of the interactions of these macromolecules and on their molecular size and shape. Analytical ultracentrifugation and mathematical modeling are the principal research techniques used. Studies on the association of fibrinogen with other proteins involved in blood clotting and fibrinolysis have been continued. Studies in progress in this area deal with the association of fibrinogen with plasma and platelet Factor XIII and with the association of plasminogen with the D and E fragments of fibrinogen. Studies on synapsin have been directed toward determining the nature of the reactions involved in the self-association of this protein.

该项目的目的是研究 各种各样的生物大分子的目标 将这些属性与结构和功能相关联 大分子。 重点是 这些大分子及其分子大小的相互作用 和形状。 分析性超速离心和数学 建模是所使用的主要研究技术。 关于纤维蛋白原与其他蛋白质的关联的研究 涉及血液凝结和纤维蛋白溶解。 该领域正在进行的研究涉及 血浆和血小板因子XIII以及带有纤维蛋白原以及 纤溶酶原与D和E片段的缔合 纤维蛋白原。 关于突触素的研究已针对确定 自我关联的反应的性质 蛋白质。