GENERATION OF NEURONAL FORM AND FUNCTION

神经元形态和功能的生成

基本信息

批准号：
3099530
负责人：
JEFFREY L DENBURG
金额：
$ 54.34万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
起止时间：
1979-07-01 至 1994-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3099530
关键词：
developmental neurobiology neurogenesis

项目摘要

Each proposal in this program project is concerned with cellular developmental neurobiology. The central hypothesis of these proposals is that there is a continuous interaction between the determinants of neuronal form and function, and that these interactions play an essential role in establishing the characteristics of the differentiated neuron. Although the basic analyses by these projects has been at the cellular level, there is an increased tendency to now carry these through to the molecular level. This is explicit in the application of hybridoma techniques by each of the projects. Some will use the monoclonal antibodies as labels for subsets of neurons to increase the resolution of the cellular analyses. Others will use the monoclonal antibodies to directly assist in the identification of molecules that are directly playing an important role in developmental processes. This shared interest in the cellular events occurring during the development of the nervous system and in the application of hybridoma techniques has resulted in many productive interactions and direct collaborations among all participants. Both invertebrate and vertebrate nervous systems are used in order to take advantage of specific properties of each. Those projects examining the factors controlling cell number by influencing rates of cell production or cell death will contribute to our understanding of degenerative disorders like Huntington's, Parkinson's and Alzheimer's diseases. The development of neuronal control of the endocrine system in cockroaches and identification of the neuropeptides involved will produce information useful in regulating excessive populations of insects. Some projects are studying axon growth - the effect of neuronal activity on it and the function and regulation of synthesis of molecules present in cells only during this process. Other projects study the specificity of synapse formation. Knowledge of the factors mediating axon growth and synapse formation obtained from these projects will be useful for developing more rational therapeutic treatments of neuronal damage from strokes, multiple sclerosis and direct injury.

该计划项目中的每个建议都与蜂窝有关发育神经生物学。这些的中心假设提议是，神经元形式和功能的决定因素，并且互动在建立分化神经元的特征。虽然是基本的这些项目的分析一直处于细胞水平，有现在增加了将它们延伸到的趋势分子水平。这在杂交瘤的应用中是明确的每个项目的技术。有些会使用单克隆抗体作为神经元亚群的标签，以增加细胞分析的分辨率。其他人会使用单克隆抗体直接帮助鉴定直接在发展过程。这种对蜂窝的兴趣共同的兴趣神经系统发展期间发生的事件在杂交瘤技术的应用中，已导致许多生产互动和直接合作参与者。无脊椎动物和脊椎动物神经系统均在为了利用每种特定属性。那些通过检查单元格数的因素的项目影响细胞生产或细胞死亡的速率将有助于为了理解亨廷顿的退化性疾病，帕金森氏症和阿尔茨海默氏病。发展的发展蟑螂内分泌系统的神经元控制和鉴定涉及的神经肽将产生信息可用于调节昆虫过多的人群。一些项目正在研究轴突生长 - 神经元的影响它的活动及其合成的功能和调节仅在此过程中存在于细胞中的分子。其他项目研究突触形成的特异性。了解介导轴突生长和突触形成的因素从这些项目中，将有助于发展更合理的中风的神经元损害的治疗治疗，多个硬化症和直接受伤。