PRENATAL EFFECTS OF CHEMICALS ON THE RESPIRATORY TRACT

化学品对呼吸道的产前影响

• 批准号: 3841041
• 负责人: D L MORGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3841041
• 关键词: cadmium; embryo /fetus drug adverse effect; embryo /fetus toxicology; gestational age; histology; inhalation drug administration; laboratory rat; lung; method development; pregnancy; respiratory function; respiratory system

Initial studies in this new project involve establishing a standard protocol for chemical treatment of pregnant rats with CdS02. These studies include determining which gestation days to treat and the appropriate dose in order to obtain an optimal effect on the fetal and neonatal respiratory tract. A prototype nose-only plethysmograph was constructed for measuring pulmonary function in neonatal rats during inhalation challenge to irritant gases. Initial testing and evaluation of this system is in progress. Methods for evaluating histological and biochemical endpoints are also being developed.

这个新项目的初步研究涉及建立标准 用CD02对怀孕大鼠化学处理的方案。 这些研究 包括确定要治疗的妊娠日和适当的剂量 为了获得对胎儿和新生儿呼吸系统的最佳作用 道。 构建了一个原型鼻子的原型尺寸图用于测量 吸入刺激性挑战期间新生大鼠的肺功能 气体。 该系统的初始测试和评估正在进行中。 评估组织学和生化终点的方法也是 被开发。