PRENATAL EFFECTS OF CHEMICALS ON THE RESPIRATORY TRACT

化学品对呼吸道的产前影响

• 批准号: 3755382
• 负责人: D L MORGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3755382
• 关键词: apolipoproteins; cadmium; embryo /fetus toxicology; environmental toxicology; female; gene expression; gestational age; glycogen; histology; laboratory rat; lung; mammalian embryology; newborn animals; plethysmography; pregnancy; pulmonary surfactants; respiratory function; respiratory system; respiratory toxin

In an initial experiment, pregnant Sprague-Dawley rats were administered CdCl2 on gestation days 12, 13, and 14; control rats received saline. Birth was delayed by 24 hours in CdCl2 treated dams. Placenta, fetal body, and lung weights were not affected by in utero CdCl2 exposure. However, the lungs of fetuses treated in utero contained greater amounts of glycogen than controls. In addition, about 10% of treated pups died within 1 day after birth. When the study was repeated using a larger number of pregnant dams (10 per group), 25% of pups from treated dams died within 24 hours after birth; none of the control pups died. Lungs of treated pups that died had significantly increased levels of glycogen compared to surviving treated and control pups. These preliminary data suggest that in utero exposure to CdCl2 may inhibit surfactant production possibly by interfering with glycogen utilization. In a subsequent study, treatment of pregnant dams with nicotine from gestation day 5 until birth had no effect on fetal lung weights or glycogen depletion, or on survival of neonates.

在最初的实验中，怀孕的sprague-dawley大鼠是 在妊娠第12、13和14天管理CDCL2；控制大鼠 收到盐水。 在CDCL2处理的大坝中，分娩延迟了24小时。 胎盘，胎儿和肺部体重不受子宫内的影响 CDCL2暴露。 但是，在子宫内治疗的胎儿的肺 含有大量的糖原比对照。 另外，大约 10％的幼崽在出生后1天内死亡。 研究是 使用大量的怀孕大坝重复（每组10个），25％ 出生后24小时内，经过处理的大坝的幼崽死亡；没有 控制幼犬死了。 死亡的治疗幼崽的肺有明显的 与存活的治疗和对照相比，糖原水平增加 幼崽。 这些初步数据表明，在子宫内暴露于CDCL2中 可能通过干扰糖原抑制表面活性剂的产生 利用率。 在随后的研究中，用 妊娠第5天到出生的尼古丁对胎儿肺无影响 重量或糖原消耗或新生儿的存活。