COMMUNITY CLINICAL ONCOLOGY PROGRAM

社区临床肿瘤学计划

• 批准号: 3558725
• 负责人: RODGER J WINN
• 金额: $ 64.16万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1996-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3558725
• 关键词: 13 cis retinoate; antineoplastics; biomarker; bleomycin; brain neoplasms; breast neoplasm /cancer diagnosis; breast neoplasms; bronchogenic carcinoma; cancer information system; cancer prevention; cancer registry /resource; cancer rehabilitation /care; chemoprevention; cis platinum compound; clinical trials; colorectal neoplasms; community health services; continuing education; cooperative study; cyclophosphamide; etoposide; fluorouracil; folate; gastrointestinal neoplasms; head /neck neoplasm; health science research analysis /evaluation; human subject; human therapy evaluation; interferons; lomustine; lung neoplasms; melanoma; metastasis; neoplasm /cancer chemotherapy; neoplasm /cancer education; neoplasm /cancer genetics; neoplasm /cancer immunotherapy; neoplasm /cancer nutrition therapy; neoplasm /cancer radiation therapy; neoplasm /cancer therapy; nutrition related tag; oral leukoplakia; paclitaxel; pancreas neoplasms; patient /disease registry; patient care planning; prostate neoplasms; quality of life; relaxation; small cell lung cancer; tamoxifen; tocopherols; vinblastine

The overall aim of this proposal is to continue the role of UTMDACC as a Research Base in the Community Clinical Oncology Program (CCOP), by accomplishing the following objectives: 1) To provide NCI-approved treatment and cancer control protocols for CCOP participants; 2) To integrate the CCOP network into the clinical research program of UTMDACC; 3) To maintain the data management and quality assurance systems necessary to ensure data of the highest quality in this collaborative research program; 4) To develop cancer control programs which will generate a series of research protocols for CCOP investigators. The MDACC CCOP network will consist of thirty-four CCOPs in 24 states, four of which are new Minority CCOPS. It is estimated that these CCOPs will provide 537 patients (credits) for treatment protocols and 2241 subjects or 910 credits for cancer control protocols annually. Mechanisms for the development of cancer control protocols based on MDACC or CCOP concepts have been developed, utilizing CCOP staff as Principal Investigators (PI) or Co-PIs. Communication concerning the development of trials is accomplished by interactive meetings, a monthly newsletter with surveys, and a proposed electronic mail system. Data management using the MDACC computerized Protocol Data Management System has been adapted to multi-institutional trials, including a protocol data form tracking system. A complete quality assurance system has been devised. This includes a continuous monitoring of CCOP performance for eligibility, evaluability, data quality, and data timeliness. On-site audits will be performed on each CCOP every 18 months. Review of all major resources will be performed to assure concordance between MDACC and CCOP evaluations. Standardized forms and procedure manuals will be designed for all cancer control studies and appropriate quality assurance measures devised. The goal of the CCOP network is to optimize interactions between MDACC and CCOP investigators in the research of therapeutic and prevention interventions.

该提案的总体目的是继续扮演UTMDACC作为一个 社区临床肿瘤学计划（CCOP）的研究基础，作者： 实现以下目标：1）提供NCI批准 CCOP参与者的治疗和癌症控制方案； 2）到 将CCOP网络集成到UTMDACC的临床研究计划中； 3）维护数据管理和质量保证系统 确保此协作中最高质量的数据所需 研究计划； 4）制定癌症控制计划 为CCOP研究人员生成一系列研究方案。 这 MDACC CCOP网络将由24个州的34个CCOP组成，四个 其中是新的少数民族CCOP。 据估计，这些CCOP将会 为治疗方案和2241名受试者提供537名患者（学分） 或每年进行910个癌症控制方案的学分。 机制 开发基于MDACC或CCOP概念的癌症控制方案 已经开发了，利用CCOP员工担任首席研究人员（PI） 或Co-Pis。 有关试验发展的沟通是 通过互动会议完成，每月的新闻通讯，并带有调查， 和拟议的电子邮件系统。 使用MDACC的数据管理 计算机协议数据管理系统已适应 多机构试验，包括协议数据形式跟踪 系统。 已经设计了一个完整的质量保证系统。 这 包括对CCOP绩效的持续监控，以获得资格， 评估性，数据质量和数据及时性。 现场审核将是 每18个月对每个CCOP进行一次。 审查所有主要资源 将执行以确保MDACC和CCOP之间的一致性 评估。 标准化表格和程序手册将设计 对于所有癌症控制研究和适当的质量保证措施 设计。 CCOP网络的目标是优化交互 MDACC和CCOP研究人员在治疗研究中 预防干预措施。