TOXICITY OF CHEMICALS USED IN THE SEMICONDUCTOR INDUSTRY

半导体行业使用的化学品的毒性

• 批准号: 3777452
• 负责人: D L MORGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3777452
• 关键词: cadmium; copper; cytotoxicity; diagnostic respiratory lavage; dosage; environmental toxicology; gallium; indium; industry; inhalation drug administration; laboratory rat; metal poisoning; neutrophil; pharmacokinetics; respiratory pharmacology; respiratory toxin; selenium; semiconduction; tellurium

The objective of these studies is to investigate the absorption, distribution and pulmonary toxicity of several novel chemicals used in the semiconductor and photovoltaic industries. The first 3 chemicals to be evaluated are copper-indium diselenide (CIS), copper-gallium diselenide (CGS) and cadmium telluride (CdTe). These chemicals were selected because of their increasing use, the potential for inhalation exposure, and the lack of pharmacokinetic/toxicity data. In an initial range-finding study, female Sprague-Dawley rats were administered 2.5, 5, 10, or 20 mg CIS per animal by intratracheal instillation, and sacrificed 72 hours later. Lung weights were significantly increased in all treatment groups. Evaluation of bronchoalveolar lavage fluid (BALF) cellularity revealed a significant influx of neutrophils (PMNs) at dose levels of 5 mg and above. Studies are in progress to follow the progression of CIS pulmonary toxicity at lower doses and a longer duration, as well as to investigate the pharmacokinetics of CIS. Comparative studies will be conducted with CGS and CdTe.

这些研究的目的是调查吸收， 几种新型化学物质的分布和肺毒性 半导体和光伏产业。 前 3 种化学品 被评估的是铜-铟二硒化物（CIS）、铜-镓 二硒化物（CGS）和碲化镉（CdTe）。 这些化学品是 选择的原因是它们的使用量不断增加，有可能被吸入 暴露以及缺乏药代动力学/毒性数据。 在最初的 测距研究，雌性 Sprague-Dawley 大鼠被给予 2.5， 通过气管内滴注给每只动物 5、10 或 20 mg CIS，以及 72小时后牺牲。 肺重量显着增加 所有治疗组。 支气管肺泡灌洗液（BALF）的评估 细胞结构显示在剂量下中性粒细胞 (PMN) 显着涌入 5毫克及以上的水平。 研究正在进行中，以遵循 较低剂量和较长时间下 CIS 肺毒性的进展 持续时间，以及研究 CIS 的药代动力学。 将与 CGS 和 CdTe 进行比较研究。