RECRUITMENT OF UNRELATED BONE MARROW DONORS

招募无关的骨髓捐赠者

基本信息

批准号：
3441985
负责人：
Jay E Menitove
金额：
$ 7.3万
依托单位：
VERSITI WISCONSIN, INC.
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-07-01 至 1986-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3441985
关键词：
blood banks blood donor bone marrow transplantation health behavior health care service evaluation health service demonstration project human subject leukocyte antigen typing

项目摘要

Although bone marrow transplantation is currently the treatment of choice for several forms of leukemia and aplastic anemia, this therapy is unavailable for more than 60% of the patients because compatible family donors do not exist. Technological advances in histocompatability testing and improvement in post-transplant care have made it feasible to consider transplants from non-related donors for some patients. Two such transplants have been performed at Milwaukee Children's Hospital within the past year and one was previously undertaken in Seattle. Each was successful. The extreme polymorphism of the HLA system requires large numbers of willing donors to be screened prior to finding one who is potentially compatible. The Blood Center of Southeastern Wisconsin currently maintains a pool of 10,000 active blood donors who are HLA-typed. Recruitment of blood donors as bone marrow donors raises many questions of key importance to a regional blood program. We propose to determine if it is feasible to recruit non-related bone marrow donors from our HLA-types population; whether a pool of 10,000 individuals is sufficient for this task; how the various functions related to recruitment of non-related bone marrow donors should be divided between blood center, hospital and transplant team; the positive and negative effects on the overall blood donor recruitment effort; and the psychological and personal reactions of bone marrow donors, those who decline to donate and those found not compatible. We also propose to recruit donors for patients at the Fred Hutchinson Cancer Center in Seattle and to evaluate the many problems likely to be encountered in sending donors to a distant city. The latter objective is of considerable significance if this therapy becomes more generally available, since donors and recipients will not always reside in close geographic proximity. If successful, it should be possible for our program to be used as a model for recruitment of donors by other blood centers interested in developing this capability.

虽然骨髓移植是目前的首选治疗方法对于多种形式的白血病和再生障碍性贫血，这种疗法是超过60%的患者因家庭和谐而无法就诊捐助者不存在。组织相容性测试的技术进步以及移植后护理的改善使得考虑一些患者接受非亲属捐献者的移植。两个这样的移植手术已在密尔沃基儿童医院进行去年，其中一次是在西雅图进行的。每个都是成功的。 HLA系统的极端多态性需要大量在找到合适的捐赠者之前需要对愿意捐赠者的数量进行筛选潜在兼容。威斯康星州东南部血液中心目前拥有 10,000 名活跃的献血者 HLA 型。招募献血者作为骨髓捐献者筹集了许多对区域血液计划至关重要的问题。我们建议确定是否可以从以下来源招募非亲属骨髓捐献者我们的 HLA 型人群；是否有 10,000 人的池足以完成这项任务；各个职能如何与招聘相关非血缘关系的骨髓捐献者应在血液中心、医院和移植团队；的积极和消极影响总体献血者招募工作；以及心理和个人骨髓捐献者、拒绝捐献者和骨髓捐献者的反应发现不兼容。我们还建议为患者招募捐赠者西雅图 Fred Hutchinson 癌症中心并评估了许多将捐赠者送往遥远城市时可能会遇到的问题。这如果这种疗法成为，后一个目标将具有相当大的意义更普遍，因为捐助者和接受者并不总是居住在地理上接近的地方。如果成功的话应该是可以的让我们的计划成为其他组织招募捐助者的典范血液中心对发展这种能力感兴趣。