Host-Guest Complexation: A Modular Approach for Structural Control (MAS-Control) in Supramolecular Polymerization

主客体络合：超分子聚合中结构控制（MAS-Control）的模块化方法

• 批准号: EP/Y027965/1
• 负责人: Souvik Sarkar
• 金额: $ 23.84万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY027965%2F1
• 关键词: Host; Guest; Complexation; Modular; Approach

Key principles to attain enhanced functional efficiency among organic soft materials often rely on mechanisms regulating structures and their controlled organization by defining and dictating their size and dispersity. While addressing the associated grand challenges, supramolecular chemists have mastered the art of engineering molecular self-assembly process under kinetic conditions, either by virtue of introduced conformational changes in the molecular structures of the monomers or via the off-nucleation process. The available reports are limited to specific molecular structures of the monomers, and this necessitates exploration of programmable polymeric structures to advance the field of supramolecular chemistry. The major objective of this proposal is to develop a universal and modular design strategy for structural control in supramolecular polymers, applicable to any molecular design. The proposal aims at achieving high programmability in the kinetic profiles by the host-guest supramolecular complexation of the monomer building blocks to create a kinetically trapped state, to begin with. In the next step, external stimuli-triggered host-guest decomplexation of monomer building blocks will be harnessed to enable kinetically controlled growth processes. Further, by modulating the extent of external stimulation, the supramolecular polymeric system will be advanced with the programmable structural organization. Thus, reaching this goal is the key to unravel the existing challenges of structural control, and herein proposed "host-guest chemistrya modular and universal approach" to programming molecular self-assembly process with controlled size and dispersity- is very appropriate. This planned research will be a paradigm shift and will train the next generation of scientists, technologists, and innovators in a range of new concepts, and topics for realizing soft functional materials.

实现有机软材料中提高功能效率的关键原则通常依赖于通过定义和决定其规模和分散性来调节结构及其受控组织的机制。在应对相关的巨大挑战的同时，超分子化学家掌握了在动力学条件下工程分子自组装过程的艺术，要么是由于单体的分子结构引入了构象变化，要么是通过核分裂过程的构象变化。可用的报告仅限于单体的特定分子结构，这需要探索可编程聚合物结构以推进超分子化学领域。该提案的主要目的是制定一种适用于任何分子设计的超分子聚合物中的结构控制的通用和模块化设计策略。该提案旨在通过单体构建块的宿主 - 环境超分子络合物在动力学概况中实现高的可编程性，以创建一个动力学捕获的状态。在下一步中，将利用外部刺激触发的宿主 - 宿主解解构建块，以实现动力学控制的生长过程。此外，通过调节外部刺激的程度，超分子聚合系统将通过可编程结构组织提出。因此，实现这一目标是揭示结构控制的现有挑战的关键，在此提出的“宿主 - 阵线化学模块化和通用方法”，用于以控制大小和分散性的方式编程分子自组装过程 - 非常合适。这项计划的研究将是一个范式的转变，并将以一系列新概念培训下一代的科学家，技术人员和创新者，以及实现软功能材料的主题。