ANALYSIS OF PEPTIDES, PROTEINS, AND METABLITES USING MASS SPECTROMETRY

使用质谱分析肽、蛋白质和代谢物

• 批准号: 3757618
• 负责人: H M FALES
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3757618
• 关键词: ADP ribosylation; biological products; chemical stability; chemical synthesis; corticotropin releasing factor; dolichol; electrospray ionization mass spectrometry; fatty acylation; guanine nucleotide binding protein; hemoglobin; hormone receptor; oxidation; silicon; synthetic peptide

A wide variety of problems has been attacked using a combination of electrospray and MALDI mass spectrometry. An 85 carbon dolichol has been identified in connection with Hermansky-Pudlak albinisim, reactive monomeric silicones have been found in silicone breast implants, oxidation of proteins as putative aging processes have been studied, a series of synthetic phosphorylated peptides related to insulin have been analyzed to guide their synthesis, altered states of hemoglobin have been identified, and the stability of corticotropin releasing factor receptor with various putative peptides has been examined. In addition, the nature of the myristoylated human adenosine ribosylation factor has been found to be complex.

使用的组合已经攻击了各种各样的问题 电喷雾和MALDI质谱法。 85个碳多利科是 与Hermansky-Pudlak Albinisim相关，反应性 在有机硅乳房植入物中发现了单体硅酮， 已经研究了蛋白质作为推定衰老过程的氧化， 与胰岛素相关的一系列合成磷酸化肽已经 被分析以指导其合成，血红蛋白的改变状态已经 确定的，以及皮质激素释放因子受体的稳定性 已经检查了各种推定的肽。 另外， 肉豆蔻酰化的人腺苷核糖基化因子的性质已经 发现很复杂。