Every Ion Counts: 4-D Mass Spectrometry

每个离子都很重要：4-D 质谱

• 批准号: EP/Y003519/1
• 负责人: Barry Smith
• 金额: $ 21.13万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY003519%2F1
• 关键词: Every; Ion; Counts; Mass; Spectrometry

Recent innovations have elevated mass spectrometry (MS) into a ubiquitous and indispensable analytical technique. However, the increasing complexity of the instrument has gradually turned it into a closed system whereby specific methods are suitable for only a narrow range of well-defined applications/analyses. We propose a new and radical approach to how we perform ion spectrometric analyses - new modes of operation for such experiments. The key enabler of this concept relies on two novel modes for MS analysis in which contrasting polarities are accessible in addition to the traditional positive and negative modes - what we have termed "four dimensional (4D) MS". The 4D MS strategy has potential to generate up to 50% more analytical data, and to enable new experiments including isomer differentiation, enhanced mixture classification and high confidence molecular weight assignments on any ordinary standalone mass spectrometer. This project can lead to the formation of new MS capability providing a means for more comprehensive measurement by way of 4D-MS.

最近的创新已将质谱 (MS) 提升为一种普遍且不可或缺的分析技术。然而，仪器日益复杂，已逐渐将其变成一个封闭系统，其中特定方法仅适用于一小部分明确的应用/分析。我们提出了一种新的、激进的方法来执行离子光谱分析——此类实验的新操作模式。这一概念的关键推动因素依赖于两种新颖的 MS 分析模式，除了传统的正负模式之外，还可以使用对比极性 - 我们称之为“四维 (4D) MS”。 4D MS 策略有可能生成最多 50% 的分析数据，并能够在任何普通独立质谱仪上进行新实验，包括异构体区分、增强的混合物分类和高置信度分子量分配。该项目可以形成新的 MS 功能，为通过 4D-MS 进行更全面的测量提供手段。