CORE--OUTPATIENT CARE AND LONG-TERM PEDIATRIC CARE

核心——门诊护理和长期儿科护理

• 批准号: 3749244
• 负责人: KEITH M SULLIVAN
• 金额: --
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3749244
• 关键词: acute leukemia; adolescence (12-20); biomedical facility; bone marrow transplantation; child physical development; graft versus host disease; homologous transplantation; hormone therapy; hospitals; human puberty; human subject; hypothyroidism; magnetic resonance imaging; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neuropsychological tests; outpatient care; patient care; pediatric neoplasm /cancer

The clinical objectives of the Outpatient Department are to support all clinical investigations of the Program Project by providing outpatient treatment and follow-up care for all patients involved in the research programs. An aim of this activity is to expand the role of ambulatory care, augmenting clinic/home care, thus reducing hospital days and cost. The research objective of the core is to investigate the delayed effects of pretransplant preparative regimens on growth, development and psychological function of children. The specific aims are: 1) to determine and compare the impact of chemotherapy only and TBI preparative regimens on the incidence and time to occurrence of endocrine abnormalities and to determine if treatment with specific hormones will improve growth rates, and 2) to determine and compare the impact of chemotherapy only and TBI regimens on the incidence and time of appearance of neuropsychological abnormalities. Prospective longitudinal endocrine and psychological studies will identify patients who require treatment. This approach will increase understanding of these late effects of transplantation and determine if early treatment with hormone supplementation will result in improved growth for these children.

门诊部的临床目标是支持所有 通过提供门诊服务来进行该计划项目的临床研究 参与研究的所有患者的治疗和后续护理 程序。 这项活动的目的是扩大门诊的作用 护理，加强诊所/家庭护理，从而减少住院天数和费用。 核心的研究目标是调查延迟效应 移植前的生长、发育和心理准备方案 儿童的功能。 具体目标是：1）确定和比较 单纯化疗和 TBI 准备方案对 内分泌异常的发生率和发生时间 确定特定激素治疗是否会提高生长速度， 2) 确定并比较单纯化疗和 TBI 的影响 治疗方案对神经心理症状发生率和出现时间的影响 异常。 前瞻性纵向内分泌和心理 研究将确定需要治疗的患者。 这种方法将 增加对移植的这些后期影响的了解 确定早期补充激素治疗是否会导致 改善这些孩子的成长。