CORE--POSTTRANSPLANT

核心——移植后

• 批准号: 6300144
• 负责人: KEITH M SULLIVAN
• 金额: $ 34.64万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-26 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6300144
• 关键词: behavioral /social science research tag; biomedical facility; bone marrow transplantation; child (0-11); clinical research; health care quality; health care service utilization; human mortality; human subject; learning disorders; leukemia; lung disorder; neuropsychological tests; neuropsychology; outcomes research; posthospitalization care; quality of life; somatotropin

The posttransplant care outlined in Core H supports intensive ambulatory treatment before and after allogeneic transplant for all patients treated according to protocols presented in all projects of this Program Project. This Core also provides assistance to referring physicians in long-term posttransplant management of pediatric transplant patients. The major objectives are (1) to improve ambulatory care of the allogeneic transplant recipient in the outpatient department in the center and in the home community, and (2) to improve the long-term quality of life for children after marrow transplantation. The first objective evaluates discharge home at day 60 (early discharge) of medically stable ambulatory patients to determine the outcome for patients treated at the transplant center and in the home community. Data regarding hospitalizations and health care utilization will be utilized to design ways to assist community providers in the care of posttransplant allogeneic recipients. For the second objective, improvements in long-term quality of life of children after transplant, a number of studies will be conducted including: (a) studies to improve the final adult height of children through early administration of growth hormone and/or sex hormone, (b) a longitudinal study of neuropsychological function and time of appearance of learning disabilities among children receiving different preparative regimens, (c) a study of the incidence and progression of pulmonary disease among children surviving greater than or equal to 5 years after transplant, and (d) a study of the quality of survival of adult survivors of a childhood marrow transplant to evaluate whether these individuals are comparable with adult survivors of an adult transplant. The goal of Core H is to improve posttransplant survival and quality of care of children through early diagnostic and interventive strategies.

核心H中概述的移植后护理支持密集 同种异体移植前后的门诊治疗 根据所有项目中介绍的方案进行治疗的患者 这个程序项目。 该核心还为参考提供了帮助 长期移植后儿科治疗的医生 移植患者。 主要目标是（1）改进 同种异体移植接受者的门诊护理 中心和家庭社区的门诊部，以及 （2）改善骨髓后儿童的长期生活质量 移植。 第一个目标评估一天的出院 60（早期出院）医学稳定的门诊患者 确定在移植中心治疗的患者的结果 在家庭社区。 有关住院和 医疗保健利用将用于设计协助的方法 社区提供者，照顾移植后同种异体 收件人。 对于第二个目标，长期改善 移植后儿童的生活质量，许多研究将 进行包括：（a）提高最终成人身高的研究 通过早期给予生长激素和/或的儿童 性激素，（b）神经心理学功能的纵向研究 儿童学习障碍的出现时间 接受不同的制备方案，（c）对发生率的研究 幸存的儿童肺部疾病的进展 大于或等于移植后5年，以及（d）研究 童年骨髓成年幸存者的生存质量 移植以评估这些人是否与 成人移植的成年幸存者。 核心H的目标是 改善移植后生存和儿童护理质量 通过早期诊断和干预策略。