Hyperpolarised portable NMR for targeted analytical solutions beyond the laboratory (HYPERSOL)

超极化便携式 NMR，用于实验室以外的目标分析解决方案 (HYPERSOL)

• 批准号: EP/X03528X/1
• 负责人: Meghan Halse
• 金额: $ 219.43万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX03528X%2F1
• 关键词: Hyperpolarised; portable; NMR; targeted; analytical

In science, access to new data drives innovation. Disruptive technologies transform research by providing quantitativeinformation in a simple and cost-effective way. Consider, for example, the impact of gene sequencing technology onapplications from human health to forensics. Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique thathas revolutionised the physical and biological sciences. However, standard NMR spectrometers are large and expensive,meaning they are confined to dedicated technical facilities. The potential to generate a step change in NMR exists if thedetector could be taken out of the lab and brought to the sample. The challenge is to achieve this without sacrificing thesensitivity and chemical resolving power of laboratory NMR. The unique innovation of the Hyperpolarised NMR Solutionsbeyond the Laboratory (HyperSoL) project is a new method to amplify the NMR response of hydrogen and carbon by factorsof >1000-fold. By accessing chemical information about carbon as well as hydrogen, this method will enhance both thesensitivity and chemical discrimination of portable NMR devices. The HyperSoL project will develop two approaches basedon both commercial and bespoke NMR instrumentation. These methods will maintain instrument portability, while amplifyingsensitivity and chemical resolution for quantifying analytes at natural isotopic abundance. Harnessing this new portable NMRtechnology will liberate NMR from the laboratory, transforming the way that it is used in such disparate areas asmanufacturing, environmental monitoring, forensics and field testing. The fundamental advances that are required tosuccessfully realise this vision can be uniquely delivered by the PI, who has an international track record in advancing NMRdevelopment through fundamental nuclear spin research. This grant would provide the PI with the necessary resources toconsolidate her position as a world-leader in portable NMR technology development.

在科学上，访问新数据推动了创新。破坏性技术通过简单且具有成本效益的方式提供定量信息来改变研究。例如，考虑基因测序技术从人类健康到取证的影响。核磁共振（NMR）光谱是一种强大的技术，它彻底改变了物理和生物科学。但是，标准的NMR光谱仪大且昂贵，这意味着它们仅限于专用的技术设施。如果可以从实验室中取出并将其带入样品，则存在NMR的步骤变化的潜力。面临的挑战是在不牺牲实验室NMR的敏感性和化学解决能力的情况下实现这一目标。实验室（Hypersol）项目的超极化NMR溶液的独特创新是一种新方法，可以通过> 1000倍的因子扩增氢和碳的NMR响应。通过访问有关碳和氢的化学信息，该方法将增强便携式NMR设备的敏感性和化学区分。 Hypersol项目将开发两种基于商业和定制NMR仪器的方法。这些方法将保持仪器的可移植性，而在自然同位素丰度下进行量化分析物的扩增强度和化学分辨率。利用这一新的便携式NMRTECHNOLOGY将使NMR从实验室中解放出来，从而改变了它在这种不同的地区使用，环境监测，取证和现场测试的方式。 PI可以通过基本的核旋转研究具有国际往绩来实现的基本进步，这是PI可以独特地实现这种愿景的基本进步。这笔赠款将为PI提供必要的资源，以掩盖她作为便携式NMR技术开发领域的世界领导者的地位。