UNMC/EPPLEY CANCER CENTER SUPPORT GRANT

UNMC/EPPLEY 癌症中心支持补助金

• 批准号: 2089157
• 负责人: RAYMOND W RUDDON
• 金额: $ 102.27万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-28 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2089157
• 关键词: biomedical facility; chemical carcinogenesis; biomedical facility; chemical carcinogenesis

The specific aims of the UNMC/Eppley Center for Cancer Research and Cancer Care (UNMC/Eppley Cancer Center) are to carry out interdisciplinary basic and translational research in: 1) Cancer Cause and Prevention, aimed at determining the mechanisms of action of chemical carcinogens, including the mechanisms of activation of carcinogen and their interactions with DNA, the role of potential environmental carcinogens in human cancer, the interaction of oncogenes and chemical carcinogens in tumor initiation and promotion, and the role of dietary factors in causing and preventing cancer; 2) Molecular, Cellular, and Structural Biology, focused on mechanisms of gene transcriptional regulation, characterization of growth factor receptors and their signal transduction mechanisms, the role of oncogene expression in cellular differentiation, mechanisms of viral reproduction and oncogene activation, DNA-protein interactions, and structural characterization of tumor-derived proteins, glycoproteins, and mucins; and 3) Developmental Therapeutics, directed at isolation and characterization of tumor- associated antigens and development of monoclonal antibodies to them, development and clinical use of radioimmunoconjugates for cancer diagnosis and treatment, use of autologous bone marrow, peripheral stem cells, and cytokines in bone marrow rescue, the development of oligonucleotide-based therapies for cancer, and the development of tumor vaccines. To achieve these specific aims we have assembled a group of 90 faculty with expertise in chemistry, biochemistry, cell biology, molecular biology, immunology, pathology, virology, pharmacology, toxicology, nutrition, and clinical oncology. In support of this research we have established core laboratory facilities in animal care, cell culture, histology, molecular biology, mass spectrometry, nuclear magnetic resonance spectrometry, computer services including molecular modeling and DNA and protein data base analysis, microbial mutagenesis, glassware washing, and safety. In addition, we have established a Tissue Procurement Core that supports a region-wide research program on lymphoproliferative diseases. The Core Grant faculty also comprise the nucleus of our NCI-funded Cancer Biology Training Program for the education and research training of predoctoral and postdoctoral students.

UNMC/Eppley癌症研究中心的具体目的 癌症护理（UNMC/Eppley癌症中心）将进行 跨学科基础研究和转化研究：1）癌症原因 和预防，旨在确定化学作用机理 致癌物，包括致癌的激活机制 它们与DNA的相互作用，潜在环境的作用 人类癌症中的致癌物，癌基因与化学的相互作用 致癌物在肿瘤开始和促进中以及饮食的作用 导致和预防癌症的因素； 2）分子，细胞和 结构生物学，侧重于基因转录的机制 调节，生长因子受体的表征及其信号 转导机制，癌基因在细胞中的作用 分化，病毒繁殖的机制和癌基因 激活，DNA-蛋白质相互作用和结构表征 肿瘤来源的蛋白质，糖蛋白和粘蛋白； 3）发展 治疗剂，致力于分离和表征肿瘤 相关的抗原和对它们的单克隆抗体的发育， 放射免疫缀合物的开发和临床用途用于癌症 诊断和治疗，自体骨髓的使用，周围茎 细胞和骨髓营救中的细胞因子，发展 基于寡核苷酸的癌症疗法和肿瘤的发展 疫苗。 为了实现这些特定目标，我们组装了一组90个教职员工 具有化学，生物化学，细胞生物学，分子的专业知识 生物学，免疫学，病理学，病毒学，药理学，毒理学， 营养和临床肿瘤学。为了支持这项研究 在动物护理，细胞培养中建立的核心实验室设施， 组织学，分子生物学，质谱法，核磁性 共振光谱，计算机服务，包括分子建模 以及DNA和蛋白质数据库分析，微生物诱变，玻璃器皿 洗涤和安全。 此外，我们已经建立了一个组织 支持范围内研究计划的采购核心 淋巴增生性疾病。 核心赠款教师还包括 我们NCI资助的癌症生物学培训计划的核 对学位和博士后学生的教育和研究培训。