PRODUCTION OF RETROVIRUS STOCKS FOR AIDS RESEARCH

用于艾滋病研究的逆转录病毒库存的生产

• 批准号: 2297262
• 负责人: JEFFREY M OSTROUR
• 金额: $ 7.02万
• 依托单位: MICROBIOLOGICAL ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-15 至 1993-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2297262
• 关键词: PRODUCTION; RETROVIRUS; STOCKS; AIDS; RESEARCH

NIAID is playing a central role in the investigation of the disease known as Acquired Immunodeficiency Syndrome or AIDS. Research efforts directed toward the epidemiology, prevention, pathogenesis and treatment of the disease and its sequelae have intensified. The control of AIDS will require studies to understand the host immune system and its interactions with HIV and related retroviruses. Research to understand the biology of viral host interactions, to develop vaccines to prevent infection, to develop antiviral drugs to treat already infected individuals and to develop methods to boost or reconstitute the immune system will be assisted by establishing a series of standardized retroviral stocks for the scientific community. It is the purpose of this solicitation to support research activities of the scientific community and the AIDS Program by providing stocks of standardized HIV, SIV and related retrovirus stocks. Some virus stocks are available but the need for a centralized resource to provide these materials is essential. The NIAID needs access to significant quantities of the noted materials to support the efforts of the National Cooperative Drug Discovery Groups, the National Vaccine Developmental Groups, the AIDS Clinical Study Groups, the Programs of Excellence in Basic Research on AIDS, and other more specific programs initiated by NIAID.

Niaid在调查该疾病中起着核心作用 被称为获得的免疫缺陷综合征或艾滋病。 针对流行病学，预防， 疾病及其后遗症的发病机理和治疗 加强。 艾滋病的控制将需要研究才能理解宿主 免疫系统及其与艾滋病毒及相关的互动 逆转录病毒。 了解病毒宿主的生物学的研究 相互作用，开发疫苗以防止感染，发展 抗病毒药以治疗已经感染的个体并发展 提高或重建免疫系统的方法将是 通过建立一系列标准化逆转录病毒库存来协助 对于科学界。 这是支持研究活动的目的 通过提供科学界和艾滋病计划 标准化艾滋病毒，SIV及相关逆转录病毒库存的库存。 有一些病毒库存可用，但需要集中式库存 提供这些材料的资源至关重要。 尼亚德需要 获取大量著名材料以支持 国家合作毒品发现小组的努力， 国家疫苗发展组，艾滋病临床 研究小组，基础研究卓越计划 艾滋病和其他由NIAID发起的更具体的计划。