IN VIVO MICRONUCLEUS TESTS

体内微核测试

• 批准号: 2308302
• 负责人: GREGORY EREXSON
• 金额: $ 14.17万
• 依托单位: ENVIRONMENTAL HEALTH RESEARCH & TESTING
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-01 至 1996-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308302
• 关键词: VIVO; MICRONUCLEUS; TESTS

The objective of this contract is to provide methods development and testing capacity that will permit the Cellular and Genetic Toxicology Branch to continue its improvement, assessment and application of short term, in vivo tests for genetic toxicity. This award will include projects involving tests for micronuclei, chromosomal aberrations and sister- chromatoid exchanges in mice and the development of testing capabilities in rats. Tests are conducted using, primarily, the bone marrow cells. Test results from these studies are used in the process of selecting chemicals for long term toxicity tests, by the Toxicology Research and Design Committee, in the overall evaluation of long term toxicity studies, and in the selection of chemicals for germ cell mutagenicity studies.

该合同的目的是提供方法开发和 测试能力将允许细胞和遗传毒理学 分支机构继续改进，评估和应用简短 术语，体内测试遗传毒性。 该奖项将包括项目 涉及微核，染色体畸变和姐妹的测试 小鼠中的染色体交换和测试能力的发展 老鼠。 主要使用骨髓细胞进行测试。 测试 这些研究的结果用于选择化学物质的过程 对于长期毒性测试，毒理学研究和设计 委员会，在长期毒性研究的总体评估中 用于生殖细胞诱变研究的化学物质。