STATISTICAL ANALYSIS OF LABORATORY ANIMAL STUDIES

实验动物研究的统计分析

• 批准号: 2308458
• 负责人: STEVEN K SEILKOP
• 金额: $ 41.43万
• 依托单位: ANALYTICAL SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308458
• 关键词: STATISTICAL; ANALYSIS; LABORATORY; ANIMAL; STUDIES

The objectives of this contract are to provide statistical and computational expertise and resources to summarize, analyze and aid in the interpretation of data from various laboratory animal experiments conducted by the National Toxicology Program (NTP). These investigations consist of subchronic studies, carcinogenesis experiments and other toxicological studies. Evaluation of NTP subchronic studies consists of providing statistical analyses of survival, organ and body weights, clinical chemistry, hematology, and pathology observations, variables which are used in the selection of doses for long-term carcinogenicity experiments. The contractor also provides support to the NTP Reproductive Assessment by Continuous Breeding Project and other special studies. For NTP long term studies, the contractor has responsibility for developing and maintaining statistical software for the Toxicology Data Management System (TDMS). This includes developing and maintaining programs for the analysis of tumor incidence and survival and providing summary statistics for food and water consumption and weight gain. The contractor is also responsible for maintaining a data base on historical control tumor incidence.

该合同的目的是提供统计和 总结、分析和帮助的计算专业知识和资源 各种实验动物实验数据的解释 由国家毒理学计划（NTP）进行。 这些调查 包括亚慢性研究、致癌实验和其他 毒理学研究。 NTP 亚慢性研究的评估包括提供统计数据 生存分析、器官和体重、临床化学、 血液学和病理学观察，变量中使用 长期致癌实验的剂量选择。 这 承包商还通过以下方式为 NTP 生殖评估提供支持： 连续育种项目和其他专项研究。 对于 NTP 长期研究，承包商有责任 开发和维护毒理学数据的统计软件 管理系统（TDMS）。 这包括开发和维护 分析肿瘤发生率和生存率并提供 食物和水消耗以及体重增加的汇总统计数据。 这 承包商还负责维护历史数据库 控制肿瘤发生率。