SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS

选定化学致癌物的合成

• 批准号: 3725503
• 负责人: PAUL H RUEHLE
• 金额: $ 27.89万
• 依托单位: CHEMSYN SCIENCE LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-12 至 1997-03-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3725503
• 关键词: adduct; aflatoxins; benzanthracenes; benzopyrenes; carbopolycyclic compound; chemical carcinogen; chemical conjugate; chemical registry /resource; chemical synthesis; chemoprevention; drug design /synthesis /production; methylcholanthrene

The objective of this contract are: (1) Resynthesis of polycyclic aromatic hydrocarbon PAH derivatives by established procedures for the restocking of NCI's Chemical Carcinogen Reference Standards Repository as necessary; and (2) Development of synthesis or purification procedures for the preparation of a wide spectrum of selected chemical carcinogens, chemopreventive agents and certain of their metabolites or derivatives.

该合同的目标是：（1）多环芳烃的再合成 碳氢化合物多环芳烃衍生物按既定程序重新进货 必要时 NCI 的化学致癌物参考标准库；和 (2) 制剂合成或纯化工艺的开发 多种选定的化学致癌物、化学预防剂 以及它们的某些代谢物或衍生物。