A Research Dedicated Mini-Cyclotron for PET Ligand Discovery

用于 PET 配体发现的研究专用微型回旋加速器

• 批准号: EP/W036428/1
• 负责人: Veronique Gouverneur
• 金额: $ 98.31万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FW036428%2F1
• 关键词: Research; Dedicated; Mini; Cyclotron; PET

Positron Emission Tomography is a non-invasive molecular imaging technology to visualise vivo chemical and biological processes. In nuclear medicine, PET scans enable the diagnosis of diseases and the monitoring of disease progression (oncology, neurodegenerative diseases and cardiology), thereby guiding personalised healthcare. In pharmaceutical drug development, PET offers vital information on in vivo biodistribution, metabolism, and target engagement. The recent availability of total-body PET scanner offers unique opportunities in imaging, not least the study of multi-systems diseases such as cancer and dementia. PET inevitably requires molecules labelled with cyclotron-produced radioisotopes that decay by emitting a positron. When these radioisotopes are short-lived fluorine-18 (110 mins), carbon-11 (20 mins), nitrogen-13 (10 mins) and oxygen-15 (2 mins), they must be generated near to the PET scanners otherwise the radioactivity will have disappeared/decayed before it can be used. The requested compact cyclotron will supply Oxford with these radioisotopes for breakthrough innovation in PET ligand and radiotracer discovery.For further advances in experimental molecular imaging including PET, innovation is paramount to produce the next generation of first-in-class PET radiotracers for usage in PET clinical centres in the UK and worldwide. We propose to create in Oxford and the Thames Valley region a discovery research centre for experimental molecular imaging that will harness world-leading local expertise in numerous aspects of underpinning sciences such as (bio)chemistry, (bio)physics, computer science, mathematics, biology, and multiple translational disciplines, to invent novel labelled (bio)molecules for PET imaging applications. New chemistry combined with artificial intelligence planning will provide highly effective and selective methods to label (bio)molecules precisely and reliably. These labelled molecules will enable a broad range of fundamental research such as in depth understanding of dynamic biological systems, or in depth understanding of plant physiology, which is incredibly important for climate-sensitive agriculture and food supply. In addition, new labelled molecules will enable early detection and more generally precision medicine to improve patient care, and facilitate the invention of novel therapeutics and diagnostics for oncology, neurodegenerative diseases and cardiology. The mini-cyclotron we request with this application is essential for this vision to materialise by providing on demand and to a large number of users, the short-lived radioisotopes necessary to invent, produce and test novel labelled (bio)molecules for PET imaging.The anticipated additional benefits include raising the profile of the UK in the field of molecular imaging and leveraging existing UK imaging infrastructure, driving interdisciplinary (inter)national collaboration with academia and industries, and accelerating knowledge exchange and skills across the various disciplines necessary for PET imaging programmes to thrive. From a socio-economic viewpoint, advances in PET imaging can enable healthcare savings, grow and create new businesses in molecular imaging, pharmaceutical and even agrochemical sciences.

正电子发射断层扫描是一种非侵入性分子成像技术，可视化体内化学和生物学过程。在核医学中，PET扫描能够诊断疾病和监测疾病进展（肿瘤学，神经退行性疾病和心脏病学），从而指导个性化的医疗保健。在药物开发中，PET提供了有关体内生物分布，代谢和目标参与的重要信息。近期全身PET扫描仪的可用性为成像提供了独特的机会，尤其是对癌症和痴呆等多系统疾病的研究。 PET不可避免地需要用循环加成产生的放射性异位素标记的分子，这些放射性异位素通过发射正电子。当这些放射性同位素是短寿命的氟-18（110分钟），碳11（20分钟），氮-13（10分钟）和氧气15（2分钟）时，必须在宠物扫描仪附近生成它们，否则放射性将消失/衰减。所需的紧凑型回旋子将为牛津提供这些放射性异位素，以在PET配体和放射性示踪剂发现中进行突破性创新。对于包括PET在内的实验分子成像的进一步进步，创新对于下一代第一代佩特宠物放射线的宠物临床临床中心是英国和全球范围内的PET临床临床中的第一代宠物。 We propose to create in Oxford and the Thames Valley region a discovery research centre for experimental molecular imaging that will harness world-leading local expertise in numerous aspects of underpinning sciences such as (bio)chemistry, (bio)physics, computer science, mathematics, biology, and multiple translational disciplines, to invent novel labelled (bio)molecules for PET imaging applications.新的化学与人工智能计划相结合将提供高效和选择性的方法来精确且可靠地标记分子。这些标记的分子将实现广泛的基础研究，例如对动态生物系统的深入了解，或深入了解植物生理学，这对于气候敏感的农业和食品供应非常重要。此外，新标记的分子将实现早期检测和更普遍的精确药物，以改善患者护理，并促进新型疗法和肿瘤学，神经退行性疾病和心脏病学的发明。我们要求使用此应用程序的迷你环境基因构想对于该愿景的构成至关重要，可以通过需求提供和对大量用户的作用，这是发明，生产和测试标记和测试的短暂的放射性病，用于PET Imaging。学术界和行业，以及在宠物成像计划中所需的各种学科中加速知识交流和技能。从社会经济的角度来看，宠物成像的进步可以促进医疗保健，在分子成像，药物，甚至农业化学科学方面发展和创造新业务。