ORAL CONTRACEPTIVES AND CARDIOVASCULAR DISEASE

口服避孕药与心血管疾病

• 批准号: 2314488
• 负责人: MICHAEL G MARMOT
• 金额: $ 17.97万
• 依托单位: UNIVERSITY OF LONDON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2314488
• 关键词: ORAL; CONTRACEPTIVES; CARDIOVASCULAR; DISEASE

The contract will support the Data Coordinating Centre of the World Health Organization Multi-National Study of Steroid Hormones and Cardiovascular Disease. This 14 nation study has been an ongoing case-control study of the risk of myocardial infarction and stroke in current and past oral contraceptive users. The NIH contract primarily provides for staff time at the central data processing and analysis centre of the WHO Study such that a series of primary, secondary, and tertiary analyses will be provided to the NIH. The University of London, accordingly, will deliver primary analytic results concerning the relative risks of stroke and myocardial infarction in Pill users compared to non-users. The secondary analytic runs will be delivered regarding the level of risk in women with one or more established cardiovascular risk factors. Finally, tertiary analyses will be delivered to the NIH concerning specific effects of particular oral contraceptive "Pill" effects, such as those attributable to estrogens or progestins. In addition to the analysis, the University of London, through a subcontract with Oxford University, will augment the data collection effort and increase the number of cases into the case-control study through the inclusion of English women living in the Oxford Health Authority region. A separate analysis of stroke from this centre will be a specific deliverable of Oxford University.

该合同将支持世界卫生的数据协调中心 组织跨国类固醇激素和心血管的跨国研究 疾病。 这项14个国家的研究一直是一项持续的案件对照研究 当前和过去的口腔中心肌梗塞和中风的风险 避孕用户。 NIH合同主要提供员工时间 在WHO研究的中央数据处理和分析中心 一系列的主要，次要和第三级分析将是 提供给NIH。 因此，伦敦大学将交付 有关中风和相对风险的主要分析结果 与非用户相比，药丸使用者的心肌梗塞。 次要 分析运行将进行有关女性的风险水平 一个或多个已建立的心血管危险因素。 最后，第三纪 分析将被交付给NIH有关的特定效果 特定的口服避孕“药丸”效果，例如可归因于 到雌激素或孕激素。 除了分析外，伦敦大学通过 与牛津大学的分包合同将增加数据收集 努力并增加病例对照研究的案件数量 通过包括居住在牛津健康中的英国妇女 权威地区。 该中心的中风单独分析将是 牛津大学的特定交付。