MAJOR HISTOCOMPATIBILITY COMPLEX IN HUMAN DISEASE

人类疾病中的主要组织相容性复合体

• 批准号: 3091689
• 负责人: J Donald Capra
• 金额: $ 41.3万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3091689
• 关键词: atopy; autoimmune disorder; immune response genes; major histocompatibility complex

This group of interlocking cooperative projects proposes to study the molecular mechanisms related to a number of devastating human conditions which have as their central feature an association with the human major histocompatibility complex. Both serologic, cellular, biochemical and molecular biological approaches will be used by a group of investigators to analyze at both the fundamental and clinical levels the role of HLA encoded gene products in the pathgenesis of various human diseases. Core facilities are requested in order to centralize resources and technology and to more efficiently utilize personnel and funds. Each of the individual projects follows directly from the laboratory to the clinic and back to the research laboratory and should provide important insights into the pathogenesis of human disease.

这组环环相扣的合作项目建议研究 与许多破坏性人类状况相关的分子机制 它们的核心特征是与人类专业的联系 组织相容性复合体。 血清学、细胞学、生化学和 一组研究人员将使用分子生物学方法来 从基础和临床两个层面分析 HLA 编码的作用 各种人类疾病发病机制中的基因产物。 核 需要设施以集中资源和技术 并更有效地利用人员和资金。 每个 各个项目直接从实验室到诊所， 回到研究实验室，应该提供重要的见解 人类疾病的发病机制。