An Aberration Corrected STEM with Integrated Science Driven AI to Quantify Dynamic Functionality in Advanced Energy Technologies and Biomaterials

利用综合科学驱动的 AI 进行像差校正 STEM，以量化先进能源技术和生物材料的动态功能

• 批准号: EP/V05385X/1
• 负责人: Nigel Browning
• 金额: $ 617.73万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV05385X%2F1
• 关键词: Aberration; Corrected; STEM; Integrated; Science

We will install a 300kV aberration corrected STEM that utilises artificial intelligence (AI) to simultaneously improve the temporal resolution and precision/sensitivity of images while minimizing the deleterious effect of electron beam damage. Uniquely, this microscope goes beyond post-acquisition uses of AI, and integrates transformational advances in data analytics directly into its operating procedures - experiments will be designed by and for AI, rather than by and for a human operator's limited visual acuity and response time. This distributed algorithm approach to experimental design, is accomplished through a compressed sensing (CS) framework that allows measurements to be obtained under extremely low dose and/or dose rate conditions with vastly accelerated frame rates. Optimizing dose / speed / resolution permits diffusion to be imaged on the atomic scale, creating wide-ranging new opportunities to characterise metastable and kinetically controlled materials and processes at the forefront of innovations in energy storage and conversion, and the wide range of novel engineering/medical functionalities created by nanostructures, composites and hybrid materials. The microscope incorporates in-situ gas / liquid / heating / cryo and straining / indentation stages to study the dynamics of synthesis, function, degradation / corrosion and regeneration / recycling on their fundamental length and time scales. It will be housed in the Albert Crewe Centre (ACC), which is a University of Liverpool (UoL) shared research facility (SRF) specialising in new experimental strategies for high-resolution/operando electron microscopy in support of a wide range of academic/industrial user projects. UoL supports all operational costs for the SRFs (service contracts, staff, consumables, etc), meaning that access to the microscope will always be "free at the point of use" for all academic users. This open accessibility is managed through a user-friendly online proposal submission and independent peer review mechanism linked to an adaptable training/booking system, which allows the ACC to provide extensive research opportunities and training activities for all users. In particular, for early career scientists, we commit experimental resources supporting UoL's commitment to the Prosper project for flexible career development and the Research Inclusivity in a Sustainable Environment (RISE) initiative that is creating a research culture maximising inclusivity and diversity synergistically with encouraging creativity and innovation. This new microscope aligns to several priority areas of research into materials, energy and personalised medicine at the UoL, priority research areas of EPSRC and national facilities in electron microscopy, imaging and materials science, and UKRI plans for infrastructure growth (https://www.ukri.org/research/infrastructure/). In addition to supporting extensive research programs at UoL linked to investments in the Materials Innovation factory (MIF), the Stephenson Institute for Renewable Energy (SIRE) and the new Digital Innovation Facility (DIF), this unique and complimentary microscope will be affiliated to and leverage from partnership with the national microscopy facilities at Harwell (ePSIC) and Daresbury (UKSuperSTEM) and the Henry Royce Institute, as well as form extensive research links to the Rosalind Franklin Institute and the Faraday Institution. We have established (and will expand through outreach activities) an extensive network of partners/collaborators from the N8 university group, Johnson Matthey and NSG, the Universities of Swansea, Birmingham, Warwick, Oxford, Cambridge, Loughborough, Edinburgh and Glasgow and Northwest UK area SME's as well as from universities in the USA, Ireland, Germany, Japan, France, Italy, Denmark, India, Singapore, China, South Africa and Spain who will create a dynamic, innovative and collaborative community driving the long-term research impact of this facility.

我们将安装 300kV 的像差校正 STEM，利用人工智能 (AI) 同时提高图像的时间分辨率和精度/灵敏度，同时最大限度地减少电子束损伤的有害影响。独特的是，这款显微镜超越了人工智能的收购后用途，并将数据分析方面的变革性进步直接集成到其操作程序中——实验将由人工智能设计并为人工智能设计，而不是由人类操作员有限的视敏度和响应时间设计并为之服务。这种实验设计的分布式算法方法是通过压缩传感 (CS) 框架实现的，该框架允许在极低剂量和/或剂量率条件下以大幅加速的帧速率获得测量结果。优化剂量/速度/分辨率允许在原子尺度上成像扩散，从而创造了广泛的新机会来表征处于能量存储和转换创新前沿的亚稳态和动力学控制材料和过程，以及各种新颖的工程/由纳米结构、复合材料和混合材料创造的医疗功能。该显微镜结合了原位气体/液体/加热/冷冻和应变/压痕阶段，以研究合成、功能、降解/腐蚀和再生/回收在其基本长度和时间尺度上的动力学。它将设在阿尔伯特·克鲁中心 (ACC)，该中心是利物浦大学 (UoL) 的共享研究设施 (SRF)，专门研究高分辨率/操作电子显微镜的新实验策略，以支持广泛的学术/工业用户项目。伦敦大学支持 SRF 的所有运营成本（服务合同、员工、消耗品等），这意味着所有学术用户始终“在使用时免费”使用显微镜。这种开放的可访问性是通过用户友好的在线提案提交和独立的同行评审机制来管理的，该机制与适应性强的培训/预订系统相关联，这使得 ACC 能够为所有用户提供广泛的研究机会和培训活动。特别是，对于早期职业科学家，我们投入实验资源，支持伦敦大学对 Prosper 项目的承诺，以实现灵活的职业发展和可持续环境中的研究包容性 (RISE) 倡议，该倡议正在创建一种研究文化，最大限度地提高包容性和多样性，同时鼓励创造力和创造力。创新。这款新型显微镜符合伦敦大学材料、能源和个性化医疗的几个优先研究领域、EPSRC 的优先研究领域和电子显微镜、成像和材料科学国家设施以及 UKRI 基础设施发展计划 (https://www .ukri.org/research/infrastruction/）。除了支持伦敦大学与材料创新工厂 (MIF)、史蒂芬森可再生能源研究所 (SIRE) 和新数字创新设施 (DIF) 投资相关的广泛研究项目外，这款独特且免费的显微镜将附属于利用与哈韦尔 (ePSIC) 和达斯伯里 (UKSuperSTEM) 的国家显微镜设施以及亨利·莱斯研究所的合作伙伴关系，并与罗莎琳德·富兰克林研究所和法拉第研究所建立广泛的研究联系。我们已经建立（并将通过外展活动扩大）来自 N8 大学集团、庄信万丰和 NSG、斯旺西大学、伯明翰大学、华威大学、牛津大学、剑桥大学、拉夫堡大学、爱丁堡大学、格拉斯哥大学和英国西北部大学的合作伙伴/合作者网络（并将通过外展活动扩大）地区中小企业以及来自美国、爱尔兰、德国、日本、法国、意大利、丹麦、印度、新加坡、中国、南非和西班牙的大学，他们将创建一个充满活力、创新和协作社区推动该设施的长期研究影响。