CNS SEROTONIN, REGULATION OF PERIPHERAL GLUCOSE METABOLISM

中枢神经系统血清素，外周葡萄糖代谢的调节

• 批准号: 3789509
• 负责人: R ESKAY
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789509
• 关键词: aggression; alcoholic beverage consumption; alcoholism antagonist; brain metabolism; epinephrine; glucose metabolism; hormone regulation /control mechanism; hypoglycemia; insulin; mood disorders; neuropharmacology; pancreas hormone; serotonin; serotonin inhibitor; serotonin receptor; stimulant /agonist

Increased alcohol preference and consumption, depressed mood, and impulsive aggression are thought to be linked in part through decreased central serotonergic (5-HT) activity. In agreement with this postulate, certain agents which increase central serotonergic neurotransmission (5-HT precursors, 5-HT uptake inhibitors, 5-HT receptor agonists) attenuate ethanol intake, improve memory function in intoxicated patients, and may improve memory functions in patients with Korsakoff's psychosis. Recently, a possible pattern of atypical glucose metabolism has emerged in alcohol abusing impulsive violent offenders with apparent central serotonergic dysfunction. In a group of impulsive offenders, hypoglycemia was noted during an oral glucose tolerance test. The observed hypoglycemia was possibly due to increased insulin secretion. It is possible that a relative hypoglycemic state or abnormal insulin levels may contribute to violent, aggressive behavior in violent offenders with apparently reduced central 5-HT activity; however, this hypothesis awaits substantially more scientific verification. Although appropriate animal studies have not been performed which demonstrate a cause and effect relationship between altered central serotonin activity and abnormal glucose metabolism, there is overwhelming evidence that appropriate glucose levels are maintained through a complex feedback system which involves the sympathoadrenalmedullary system through the glucose mobilizing hormone epinephrine and the endocrine pancreas via insulin and glucagon secretion.

增加酒精偏爱和消费，情绪低落以及 冲动性侵略被认为部分通过减少 中央血清素能（5-HT）活性。 与这个假设一致， 某些增加中央血清素能神经传递的药物（5-HT 前体，5-HT摄取抑制剂，5-HT受体激动剂）减弱 乙醇摄入量，改善陶醉患者的记忆功能，可能 改善科萨科夫精神病患者的记忆功能。 最近，可能出现了非典型葡萄糖代谢的模式 滥用冲动的暴力罪犯，明显 血清素能功能障碍。 在一群冲动罪犯中，低血糖 在口服葡萄糖耐受性测试期间注意到。 观察到 低血糖可能是由于胰岛素分泌增加所致。 这是 相对降血糖状态或异常胰岛素水平可能可能 与 显然减少了中央5-HT活性；但是，这个假设正在等待 基本上更科学的验证。 虽然合适的动物 尚未进行研究，以证明原因和作用 中央5-羟色胺活性改变与异常之间的关系 葡萄糖代谢，有大量证据表明适当 通过复杂的反馈系统维持葡萄糖水平，该系统 通过葡萄糖涉及交感神经肾上腺素系统 通过胰岛素和 胰高血糖素分泌。